Tsev - Cov khoom - Inhibitors & Agonists - Ras-Raf-MAPK-ERK Pathway Library - Paub meej

RMC -6291 CAS No.: 2641998-63-0

Chemical Structure: RMC-6291
CAS Nr.: 2641998-63-0

Xa kev nug

Hauj lwm lawm

Chemical Structure: RMC-6291

CAS Nr.: 2641998-63-0

RMC-6291

Catalog No.Qauv: URK-V2531Tsuas yog siv rau Lab.

Kev ua lom lom

RMC-6291 yog ib qho kev cog lus me me-molecule inhibitor uas tsis ntev los no tau txais kev pom zoo hauv kev tshawb fawb txog qog noj ntshav. Nws yog ib qho muaj zog thiab xaiv inhibitor ntawm cov protein kinases PIM1 thiab PIM2, ob lub hom phiaj tseem ceeb hauv kev kho mob qog noj ntshav.
RMC-6291 muaj zog tiv thaiv mob qog noj ntshav rau ntau hom qog noj ntshav, suav nrog leukemia, prostate, ntsws, thiab qog nqaij hlav cancer mis. Cov tshuaj tiv thaiv kab mob qog noj ntshav thiab ua rau apoptosis los ntawm kev cuam tshuam cov kev taw qhia qis ntawm PIM kinases.
RMC-6291 muaj cov tshuaj pharmacokinetic zoo, tsis muaj tshuaj lom, thiab muaj txiaj ntsig zoo hauv cov qauv tsiaj.
RMC-6291 nthuav tawm cov teebmeem kev sib koom ua ke nrog lwm cov tshuaj kws khomob, ua rau nws muaj peev xwm sib tw rau kev sib xyaw ua ke.

Physicochemical Properties

M.Wt	1012.26
Formula	C₅₅H₇₈FN₉O₈
CAS Nr.	2641998-63-0
Qhov tshwm sim	Khoom
Cia	Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos	Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis
Solubility
Tshuaj npe

Cov ntaub ntawv

1. Wang Z, et al. Kev tshawb nrhiav, kev sib raug zoo-kev sib raug zoo, thiab kev soj ntsuam lom neeg ntawm cov tsis muaj peptidic Pim inhibitors. Bioorg Med Chem Lett. 2015 Lub Xya Hli 1; 25(13): 2615-21.

2. Kelly KR, et al. Thawj-hauv-Human Study ntawm Pim Kinase Inhibitor, RMC-4630 (RMC-5552 / R-763), raws li Monotherapy nyob rau hauv cov neeg mob nrog Advanced Relapsed / Refractory Solid Tumors los yog NHL: Tag Nrho Kev Nyab Xeeb thiab Efficiency. J Clin Oncol. 2019 Tsib Hlis 20; 37(15_suppl): 2513-2513.

3. Mishra R, et al. PIM kinase inhibitor, RMC-4630 nthuav tawm lub zog tiv thaiv qog noj ntshav hauv AML. Cancer Res. 2018 Kaum Ob Hlis 15; 78(24 Suppl): Abstract nr 2766.