BMS -1166-N-piperidine-CO-N-piperazine CAS No.: 2447066-14-8

Chemical Structure: BMS-1166-N-piperidine-CO-N-piperazine

CAS Nr.: 2447066-14-8

 

BMS-1166-N-piperidine-CO-N-piperazine

Catalog No.Qauv: URK-V2492Tsuas yog siv rau Lab.

BMS-1166-N-piperidine-CO-N-piperazine muaj PD-1/PD-L1 ligand thiab PROTAC txuas. Qhov sib xyaw no tau nthuav tawm lub zog siab thiab kev xaiv tawm tsam PD-1/PD-L1 txoj hauv kev.

Kev ua lom lom

PD-1 (programmed cell death protein 1) yog ib qho receptor pom nyob rau hauv lub cev tsis muaj zog, thaum PD-L1 (programmed death-ligand 1) yog ligand ntawm cov qog hlwb. Thaum PD-1 khi rau PD-L1, nws inhibits kev ua haujlwm ntawm lub cev tiv thaiv kab mob, ua rau lub cev tsis muaj zog los ntawm cov qog. BMS-1166-N-piperidine-CO-N-piperazine ua haujlwm los ntawm kev xaiv khi rau PD-L1 thiab ua rau PD-L1 degradation los ntawm ubiquitin-proteasome system. Qhov no ua rau kom rov ua haujlwm ntawm lub cev tiv thaiv kab mob thiab txhim kho lawv lub peev xwm los tua cov qog hlwb.
Kev loj hlob ntawm BMS-1166-N-piperidine-CO-N-piperazine yog ib qho tseem ceeb hauv kev kho mob qog noj ntshav. Los ntawm kev tsom mus rau PD-1/PD-L1 txoj hauv kev, nws tau pom cov txiaj ntsig tau zoo hauv kev tshawb fawb ua ntej rau kev kho mob ntawm ntau hom qog noj ntshav, suav nrog melanoma, ntsws, thiab mob qog noj ntshav.
Ntau qhov kev sim tshuaj tab tom tab tom ntsuas los ntsuas kev nyab xeeb thiab kev ua tau zoo ntawm BMS-1166-N-piperidine-CO-N-piperazine hauv ntau hom mob qog noj ntshav. Yog tias cov txiaj ntsig tau zoo, nws tuaj yeem ua txoj hauv kev rau kev kho tshiab rau kev kho mob qog noj ntshav.
Hauv kev xaus, qhov kev tshawb pom ntawm BMS-1166-N-piperidine-CO-N-piperazine qhia tau tias muaj kev nce qib tseem ceeb hauv kev tshawb fawb txog qog noj ntshav. Los ntawm kev tsom mus rau PD-1/PD-L1 txoj hauv kev, nws muaj lwm txoj hauv kev zoo rau kev kho mob qog noj ntshav. Cov tshuaj no muaj peev xwm hloov kho mob qog noj ntshav thiab txhim kho lub neej ntawm ntau lab tus tib neeg.

Physicochemical Properties

Cov ntaub ntawv

1. Wang L, et al. Mol Cell. 2020; 77(5):{4}}.

2. Zhou Q, et al. Nat Commun. 2021; 12(1):{4}}.

3. Xu J, et al. OncoTargets Ther. 2021; 14: 2325 IB.

4. Zhao M, et al. Pem hauv ntej Oncol. Xyoo 2020; 10:580026.

URK-V2492_COA

URK-V2492_SDS

URK-V2492_TDS

Cim npe nrov: BMS-1166-N-piperidine-CO-N-piperazine CAS No.: 2447066-14-8, Tuam Tshoj BMS-1166-N-piperidine-CO-N-piperazine CAS No.: 2447066-14-8