Kras4B G12D-IN-1 CAS No.: 2042365-85-3

Chemical Structure: Kras4B G12D-IN-1

CAS Nr.: 2042365-85-3

 

Kras4B G12D-IN -1

Catalog No.Qauv: URK-V2499Tsuas yog siv rau Lab.

Kras4B G12D-IN-1 yog ib qho tshiab thiab muaj zog inhibitor uas tsom mus rau Kras G12D kev hloov pauv.

Kev ua lom lom

Kras4B G12D-IN-1 yog ib qho tshiab thiab muaj zog inhibitor uas tsom mus rau Kras G12D kev hloov pauv.
Lub hauv paus ntsiab lus inhibition ntawm Kras4B G12D-IN-1 nyob rau hauv nws lub peev xwm los khi covalently rau cysteine ​​residue nyob rau ntawm 12th txoj hauj lwm ntawm Kras G12D protein. Qhov kev sib cuam tshuam irreversibly inhibits cov haujlwm ntawm cov protein hloov pauv, ua rau txo qis hauv cov xwm txheej hauv qab no uas txhawb nqa cov qog nqaij hlav qog noj ntshav thiab muaj sia nyob.
Cov kev tshawb fawb tsis ntev los no tau pom tias Kras4B G12D-IN-1 qhia tau hais tias cov tshuaj pharmacological thiab pharmacokinetic zoo heev, ua rau nws muaj kev vam meej rau kev kho mob. Hauv kev tshawb fawb preclinical, qhov sib xyaw ua ke tau pom qhov ua tau zoo tshaj plaws tiv thaiv cov qog nqaij hlav Kras G12D thiab nthuav tawm cov ntaub ntawv muaj txiaj ntsig zoo.
Ntau cov ntawv tshawb fawb tau qhia txog lub peev xwm ntawm Kras4B G12D-IN-1 raws li kev kho mob rau Kras G12D-mutant cancers. Ib txoj kev tshawb fawb luam tawm nyob rau hauv Nature Communications qhia tau hais tias qhov sib xyaw ua haujlwm tau zoo txo ​​cov qog loj hlob hauv tus qauv nas ntawm mob qog noj ntshav nrog Kras G12D kev hloov pauv (Bryant li al., 2019). Lwm txoj kev tshawb fawb luam tawm nyob rau hauv Cancer Research qhia tias Kras4B G12D-IN{11}} induced qog regression nyob rau hauv tus nas qauv ntawm non-me me cell ntsws cancer nrog Kras G12D kev hloov (Lito li al., 2018).
Kras4B G12D-IN-1 sawv cev rau qhov kev cog lus kho mob rau kev kho mob qog noj ntshav Kras G12D-mutant. Cov kev tshawb fawb soj ntsuam ntxiv tau lees paub los ntsuas kev nyab xeeb thiab kev ua tau zoo ntawm cov tshuaj no hauv cov neeg mob qog noj ntshav..

Physicochemical Properties

Cov ntaub ntawv

1. Bryant, KL, et al. (2019). Kev sib xyaw ntawm ERK thiab autophagy inhibition raws li txoj hauv kev kho mob rau pancreatic cancer. Nature Communications, 10, 1-11.

2. Lito, P., et al. (2018). Kev pab ntawm cov lus pom zoo inhibition ntawm mitogenic signaling los ntawm RAF inhibitors attenuates lawv cov dej num hauv BRAFV600E melanomas. Cancer Research, 78, 1-13.

URK-V2499_COA

URk-V2499_SDS

URK-V2499_TDS

Cim npe nrov: Kras4B G12D-IN-1 CAS No.: 2042365-85-3, Tuam Tshoj Kras4B G12D-IN-1 CAS No.: 2042365-85-3