Tsev - Cov khoom - Inhibitors & Agonists - Ras-Raf-MAPK-ERK Pathway Library - Paub meej

SV 156 CAS Nr.: 873445-60-4

Chemical Structure: SV 156
CAS Nr.: 873445-60-4

Xa kev nug

Hauj lwm lawm

Chemical Structure: SV 156

CAS Nr.: 873445-60-4

SIB 156

Catalog No.Qauv: URK-V2500Tsuas yog siv rau Lab.

Kev ua lom lom

SV 156 yog ib qho tshiab me me molecule inhibitor. Lub hom phiaj ntawm tus inhibitor no yog txoj hauv kev mitogen-activated protein kinase (MAPK), ib txoj hauv kev taw qhia uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm tes, faib, thiab ciaj sia.
Lub mechanism ntawm inhibition ntawm SV 156 yog raws li nws lub peev xwm los khi thiab inhibit qhov kev ua ntawm dual-specificity phosphatase 16 (DUSP16), tseem hu ua mitogen-activated protein kinase phosphatase 7 (MKP-7), qhov tsis zoo. regulator ntawm MAPK txoj kev. Raws li qhov tshwm sim, qhov inhibition ntawm DUSP16 ua rau kev ua haujlwm ntawm MAPK txoj hauv kev thiab cov kev taw qhia qis qis uas ua rau muaj ntau yam kab mob.
Cov kev tshawb fawb tsis ntev los no tau pom tias SV 156 muaj peev xwm kho tau hauv ntau yam mob, suav nrog mob qog noj ntshav, mob o, thiab kab mob neurodegenerative. Hauv kev tshawb fawb preclinical, qhov inhibition ntawm DUSP16 los ntawm SV 156 ua rau kev ua haujlwm ntawm MAPK txoj hauv kev thiab ua rau inhibition ntawm cov qog nqaij hlav qog noj ntshav, thaum tseem txo qis kev mob ntawm cov tsiaj qauv ntawm cov kab mob inflammatory.
Kev txhim kho ntawm SV 156 tseem tab tom ua tiav, thiab ntau qhov kev sim tshuaj tau pib los sim nws txoj kev nyab xeeb thiab ua tau zoo hauv ntau qhov chaw kho mob. Tsis tas li ntawd, kev txheeb xyuas cov hom phiaj tshiab thiab kev txhim kho cov txiaj ntsig ntawm SV 156 tau raug tshawb xyuas los txhim kho nws cov tshuaj siv tshuaj thiab cov peev xwm kho mob.

Physicochemical Properties

M.Wt	415.32
Formula	C₂₁H₂₃BrN₂O₂
CAS Nr.	873445-60-4
Qhov tshwm sim	Khoom
Cia	Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos	Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis
Solubility
Tshuaj npe

Cov ntaub ntawv

1. Zhang Y, Blattman JN, Kennedy NJ, et al. Molecular pharmacology ntawm phosphate inhibitors tsom lub dual-specificity phosphatase MKP-7. Kev tshawb nrhiav tshuaj niaj hnub no. 2018; 23(10):1840-1847.

2. Sangwan V, Paliwal N, Rani M, et al. SV156, ib qho tshiab inhibitor ntawm MKP-7, tawm tsam cov teebmeem hauv macrophages thiab ua kom cov kab mob qog nqaij hlav hauv nas. International immunopharmacology. Xyoo 2019; 75:105811.

3. Yang SH, Sharrocks AD. Lub hom phiaj kev txheeb xyuas cov me me molecules ntawm kev txheeb xyuas hauv vitro ntawm cov protein-ligand kev sib cuam tshuam. Cov kws tshaj lij kev xav txog kev tshawb nrhiav tshuaj. 2017;12(1):{5}}.