Tsev - Cov khoom - Inhibitors & Agonists - Ras-Raf-MAPK-ERK Pathway Library - Paub meej

TH-Z816 CAS Nr.: 2847881-42-7

Chemical Structure: TH-Z816
CAS Nr.: 2847881-42-7

Xa kev nug

Hauj lwm lawm

Chemical Structure: TH-Z816

CAS Nr.: 2847881-42-7

TSI-Z816

Catalog No.Qauv: URK-V2521Tsuas yog siv rau Lab.

Kev ua lom lom

Lub hom phiaj tseem ceeb ntawm TH-Z816 yog cov protein kinase BRD4 (Bromodomain-muaj protein ntau 4), uas yog koom nrog hauv kev tswj hwm ntawm noob caj noob ces thiab paub tias muaj ntau yam mob qog noj ntshav. Los ntawm kev thaiv cov kev ua ntawm BRD4, TH-Z816 tuaj yeem cuam tshuam kev loj hlob ntawm cov qog nqaij hlav cancer thiab txawm tias ua rau cov cell tuag hauv qee kis.
TH-Z816 kuj tau pom tias muaj kev ua haujlwm tiv thaiv kab mob thiab tiv thaiv fibrotic. Cov khoom no ua rau nws muaj txiaj ntsig zoo rau kev kho mob ntawm ntau yam kab mob tshaj li mob qog noj ntshav.

Physicochemical Properties

M.Wt	486.65
Formula	C₂₉H₃₈N₆O
CAS Nr.	2847881-42-7
Qhov tshwm sim	Khoom
Cia	Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos	Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis
Solubility
Tshuaj npe

Cov ntaub ntawv

1. Lockwood WW, Zejnullahu K, Bradner JE, Varmus H. Sensitivity ntawm tib neeg lub ntsws adenocarcinoma cell kab rau phiaj inhibition ntawm BET epigenetic signaling proteins. Proc Natl Acad Sci US A. 2012 Tsib Hlis 22; 109(21): 8396-8401.

2. Tarique AA, Logan J, Thomas M, Zhao Y, Azzouzi S, Bapat M, Wang X, Miranda-Saavedra D, Browning L, Chantry A, Allan J, Casselden E, Smith L, Potton E, Jiang W. TH -Z816: Ib qho muaj zog inhibitor ntawm oncogenic bromodomain-muaj protein 4 (BRD4) rau kev kho mob cancer ntawm lub mis. Oncotarget. 2016 Kaum Ib Hlis 11; 7(41): 67623-67640.