TH-Z827 CAS Nr.: 2847881-81-4

Chemical Structure: TH-Z827

CAS Nr.: 2847881-81-4

 

TIAB SA 827

Catalog No.Qauv: URK-V2498Tsuas yog siv rau Lab.

TH-Z827 yog ib qho muaj zog thiab xaiv inhibitor ntawm cyclin-dependent kinase 7 (CDK7).

Kev ua lom lom

TH-Z827 (CAS No.: 2847881-81-4) yog ib qho muaj zog thiab xaiv inhibitor ntawm cyclin-dependent kinase 7 (CDK7).
Cyclin-dependent kinase 7 (CDK7) ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev hloov pauv los ntawm phosphorylating RNA polymerase II (C-terminal domain). CDK7 kuj yog ib qho tseem ceeb ntawm CDK-activating kinase (CAK) complex, uas ua rau lwm yam CDKs thiab tswj lub voj voog ntawm tes. Txawm li cas los xij, CDK7 inhibitors muaj peev xwm xaiv toxicity tawm tsam cov qog nqaij hlav, ua kom zoo dua ntawm kev vam khom ntawm cov qog nqaij hlav cancer ntawm CDK7- cov ntaub ntawv hloov kho.
CDK7 khi rau cyclins H thiab Mat1 los ua CAK, uas tuaj yeem phosphorylate thiab qhib lwm CDKs. TH-Z827 ua haujlwm raws li kev sib tw ATP-kev sib tw inhibitor ntawm CDK7, khi rau ATP-binding hnab tshos los thaiv cov txheej txheem ua kom CDK7. TH-Z827 muaj zog tiv thaiv CDK7, xaiv, thiab enzyme inhibition.
TH-Z827 tau pom tias muaj peev xwm zoo heev los kho tib neeg mob qog noj ntshav hauv cov qauv sib txawv thiab tab tom tsim los ua tus kws kho mob los ntawm Beijing Hua Medicine Ltd., lub tuam txhab tshuaj suav. ntau cov kev tshawb fawb preclinical tab tom tsim tshwj xeeb rau cov qog nqaij hlav tib neeg. Theem I qhov kev sim tshuaj rau TH-Z827 tseem tab tom nyob hauv Suav teb.
TH-Z827 yog ib tug muaj zog thiab xaiv inhibitor ntawm CDK7, uas plays lub luag hauj lwm tseem ceeb nyob rau hauv transcriptional regulation thiab cell voj voog tswj. TH-Z827 muaj lub zog siab, kev xaiv, thiab enzyme inhibition.

Physicochemical Properties

Cov ntaub ntawv

1. Bartkowiak, B., Yan, C., Greenleaf, A. et al. CDK Subunit Hloov Kev Qhia Tawm tau nthuav tawm hauv tib neeg cov kab mob qog noj ntshav.

2. Chao, SH Mechanisms ntawm CDK7 inhibitor induced transcriptional repression nyob rau hauv osteosarcoma hlwb.

3. Jiang, B., Yan, C., Li, C., et al. Kev tshawb pom ntawm 3-(2-(pyridin-4-yl)thiazol-4-ylamino) benzoic acid derivatives li muaj zog, xaiv, thiab qhov ncauj bioavailable inhibitors ntawm cyclin-dependent kinase 7.

4. Zhang, Y., Zhang, T., Wan, Y., et al. Ib qho tshiab ntawm qhov ncauj muaj inhibitor ntawm cyclin-dependent kinase 7 (CDK7) qhia txog kev txiav txim siab ntawm inhibitor potency.

URK-V2498_COA

URk-V2498_SDS

URK-V2498_TDS

Cim npe nrov: TH-Z827 CAS No.: 2847881-81-4, Tuam Tshoj TH-Z827 CAS No.: 2847881-81-4