GNE -1858 CAS No.: 2680616-96-8

Chemical Structure: GNE-1858

CAS Nr.: 2680616-96-8

 

GNE-1858

Catalog No.Qauv: URK-V2527Tsuas yog siv rau Lab.

GNE-1858 yog ib qho tshiab me me molecule inhibitor uas tau tsim los thaiv txoj kev taw qhia ntawm Rho guanine nucleotide exchange factor (RGNEF) protein. Cov protein no ua lub luag haujlwm tseem ceeb hauv kev ua kom Rho GTPases, uas tswj cov cell morphology, motility, thiab adhesion. Qhov inhibition ntawm cov txheej txheem no los ntawm GNE-1858 tau pom tias yuav txo qis kev muaj peev xwm ntawm cov qog nqaij hlav qog noj ntshav, ua rau nws muaj kev cog lus zoo rau kev kho mob qog noj ntshav.

Kev ua lom lom

GNE-1858 yog ib qho tshiab me me molecule inhibitor uas tau tsim los thaiv txoj kev taw qhia ntawm Rho guanine nucleotide exchange factor (RGNEF) protein. Cov protein no ua lub luag haujlwm tseem ceeb hauv kev ua kom Rho GTPases, uas tswj cov cell morphology, motility, thiab adhesion. Qhov inhibition ntawm cov txheej txheem no los ntawm GNE-1858 tau pom tias yuav txo qis kev muaj peev xwm ntawm cov qog nqaij hlav qog noj ntshav, ua rau nws muaj kev cog lus zoo rau kev kho mob qog noj ntshav.
GNE-1858 tawm tsam ntau yam kab mob qog noj ntshav, xws li mob qog noj ntshav mis, mob qog nqaij hlav prostate, thiab qog noj ntshav zes qe menyuam.

Physicochemical Properties

Cov ntaub ntawv

1. Premnath PN et al. (2017). Kev txheeb xyuas tus tshiab Rho guanine nucleotide exchange factor inhibitor rau kev kho mob qog noj ntshav. Nat Commun 8(1): 1182.

2. Kim JH et al. (2019). Targeting Rho GTPase txoj hauv kev rau kev kho mob qog noj ntshav. Arch Pharm Res 42(1): 1-14.

3. Wang YJ et al. (2020). Kev loj hlob ntawm me me molecule inhibitors tsom rau Rho GTPase txoj hauv kev mob qog noj ntshav. Cancer Lett 495: 34-44.

URK-V2527_COA

URk-V2527_SDS

URK-V2527_TDS

Cim npe nrov: GNE-1858 CAS No.: 2680616-96-8, Tuam Tshoj GNE-1858 CAS No.: 2680616-96-8