Hauj lwm lawm
Chemical Structure: MRTX 0902
CAS Nr.: 2654743-22-1
TIAB SA 0902(MRTX 0902)
Catalog No.Qauv: URK-V2328Tsuas yog siv rau Lab.
MRTX0902 yog lub zog muaj zog, xaiv SOS1 inhibitor nrog khi IC50 ntawm 2 nM, cellular IC50 ntawm 33 nM (pERK).
Kev ua lom lom
MRTX0902 yog lub zog muaj zog, xaiv SOS1 inhibitor nrog khi IC50 ntawm 2 nM, cellular IC50 ntawm 33 nM (pERK).
MRTX0902 displays weak to no affinity for SOS2 with IC50 of >10 awm.
MRTX0902 nthuav tawm kev cog lus muaj zog, kev xaiv, thiab raug rau hauv hom kab mob preclinical.
MRTX0902 nyob rau hauv ua ke nrog MRTX849 qhia tau hais tias ruaj regression nyob rau hauv KRasG12C NSCLC thiab CRC PDX qauv.
MRTX0902 qhia kev txhim kho kev ua tau zoo nrog osimertinib (EGFRi), VS-6766 (RAF/MEKc) hauv MAPK cov qauv qog.
Physicochemical Properties
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M.Wt |
388.475 |
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Formula |
C22H24N6O |
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CAS Nr. |
2654743-22-1 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
10 mM hauv DMSO |
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Tshuaj npe |
(R)-2-methyl-3-(1-((4-methyl-7-morpholinopyrido[3,4-d]pyridazin-1-}} yl)amino)ethyl)benzonitrile |
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Cov ntaub ntawv
URK-V2328_COAURK-V2328_SDSURK-V2328_TDSNco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: mrtx0902 cas no.:2654743-22-1
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