Hauj lwm lawm
Chemical Structure: LY-2562175
CAS Nr.: 1103500-20-4
LY -2562175(LY2562175; UAS 2562175)
Catalog No.Qauv: URK-V736Tsuas yog siv rau Lab.
LY-2562175 (LY2562175, LY 2562175) yog lub zog tshiab, xaiv, ib nrab FXR agonist nrog EC50 ntawm 193 nM.
Kev ua lom lom
LY-2562175 (LY2562175, LY 2562175) yog lub zog tshiab, xaiv, ib nrab FXR agonist nrog EC50 ntawm 193 nM.
LY-2562175 does not promote transcriptional activation of other nuclear receptor, such as GR, PR, MR and AR (EC50>10 UAS).
LY-2562175 txo LDL thiab triglycerides thaum nce HDL hauv hom kab mob preclinical.
Physicochemical Properties
|
M.Wt |
540.441 |
|
|
Formula |
C28H27Cl2N3O4 |
|
|
CAS Nr. |
1103500-20-4 |
|
|
Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
|
Solubility |
100 mM hauv DMSO |
|
|
Tshuaj npe |
6-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1- yl)-1-methyl-1H-indole-3-carboxylic acid |
|
Cov ntaub ntawv
1. Genin MJ, et al. J Med Chem. 2015 Dec 24; 58(24):9768-72.
URK-V736_COAURK-V736_SDSURK-V736_TDSNco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: ly2562175 cas no.:1103500-20-4
Xa kev nug
Koj Tseem Yuav Zoo Li
