Enzalutamide (MDV3100) CAS No.:915087-33-1
Chemical Structure: Enzalutamide
CAS Nr.: 915087-33-1
Hauj lwm lawm
Chemical Structure: Enzalutamide
CAS Nr.: 915087-33-1
Enzalutamide(MDV3100; MDV-3100; MDV 3100)
Catalog No.Qauv: URK-V625Tsuas yog siv rau Lab.
Ib qho androgen-receptor (AR) antagonist nrog IC50 ntawm 36 nM.
Kev ua lom lom
Ib qho androgen-receptor (AR) antagonist nrog IC50 ntawm 36 nM; txo qhov ua tau zoo ntawm AR nuclear translocation, thiab cuam tshuam DNA khi rau androgen teb cov ntsiab lus thiab recruitment ntawm coactivators; induces qog regression nyob rau hauv nas qauv ntawm castration-resistant human prostate cancer; hais lus muaj.
Prostate mob cancer
Pom zoo
Physicochemical Properties
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M.Wt |
464.436 |
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Formula |
C21H16F4N4O2S |
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CAS Nr. |
915087-33-1 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
10 mM hauv DMSO |
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Tshuaj npe |
Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo{{ 7}}thioxo-1-imidazolidinyl]-2-fluoro-N-methyl- |
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Cov ntaub ntawv
1. Tran C, et al. Kev tshawb fawb. 2009 Tej zaum 8; 324(5928):787-90.
2. Richards J, et al. Cancer Res. 2012 May 1;72(9):{5}}.
3. Scher H., et al. N Engl J Med. 2012 Sep 27; 367(13):1187-97.
URK-V625_COAURK-V625_SDSURK-V625_TDSNco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: enzalutamide (mdv3100) cas no.:915087-33-1
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