Hauj lwm lawm
Chemical Structure: AZD9496
CAS Nr.: 1639042-08-2
TIAB SA 9496(ZD-9496)
Catalog No.Qauv: URK-V691Tsuas yog siv rau Lab.
Lub zog, xaiv cov tshuaj estrogen receptor downregulator (SERD) nrog ER downregulation pIC50 ntawm 9.68.
Kev ua lom lom
Lub zog, xaiv cov tshuaj estrogen receptor downregulator (SERD) nrog ER downregulation pIC50 ntawm 9.68; qhia pM equipotent binding rau ob qho tib si ER thiab ER isoforms, xaiv kev khi zoo heev piv nrog progesterone (∼650-fold), glucocorticoid (∼11,{5}}fold), thiab androgen (∼36,{7} }fold) receptor LBDs; downregulator ntawm ER hauv vitro thiab hauv vivo hauv ER-zoo qauv ntawm kev mob qog noj ntshav mis thiab qhov ncauj muaj.
Mob cancer mis
Phase 1 Clinical
Physicochemical Properties
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M.Wt |
442.473 |
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Formula |
C25H25F3N2O2 |
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CAS Nr. |
1639042-08-2 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
DMSO: Ntau dua lossis sib npaug ntawm 104.5 mg / mL |
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Tshuaj npe |
2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-} methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,{18}}b]indol-1-yl] phenyl]-, (2E)- |
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Cov ntaub ntawv
1. De Savi C, et al. J Med Chem. 22 Lub Kaum Hli 2015; 58(20):8128-40.
2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar; 7(3):{4}}.
URK-V691_COAURK-V691_SDSURK-V691_TDSNco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: azd9496 cas no.:1639042-08-2
Xa kev nug
Koj Tseem Yuav Zoo Li
