AHR Antagonist 5 CAS No.: 2247953-39-3

Chemical Structure: AHR antagonist 5

CAS Nr.: 2247953-39-3

 

AHR antagonist 5

Catalog No.Qauv: URK-V2458Tsuas yog siv rau Lab.

AHR antagonist 5 tuaj yeem xaiv inhibit qhov kev ua ntawm AHR

Kev ua lom lom

AHR antagonist 5 tuaj yeem xaiv inhibit qhov kev ua ntawm AHR
AHR antagonist 5 yog ib qho me me molecule uas tau pom los inhibit qhov kev ua ntawm Aryl hydrocarbon receptor (AHR), uas yog ib qho kev hloov pauv uas muaj feem xyuam nrog ntau cov txheej txheem physiological.
AHR yog qhia los ntawm ntau hom ntaub so ntswg thiab cell, nrog rau lub cev tiv thaiv kab mob, daim siab, thiab cov ntaub so ntswg adipose. AHR tau pom los tswj cov kev qhia ntawm ntau yam noob koom nrog hauv kev loj hlob ntawm tes, sib txawv, thiab apoptosis, nrog rau kev tiv thaiv kab mob thiab cov metabolism. Nws kuj tseem koom nrog hauv kev ua kom cov xenobiotic enzymes, uas tuaj yeem ua rau cov metabolism thiab tshem tawm cov co toxins ib puag ncig.
AHR antagonist 5 khi ncaj qha rau AHR, tiv thaiv nws qhov kev ua kom muaj zog thiab kev ua haujlwm tom ntej. Qhov kev tiv thaiv no tuaj yeem pab tau los tiv thaiv lossis kho ntau yam kab mob uas cuam tshuam nrog AHR overactivation, xws li mob qog noj ntshav, o, thiab cov kab mob metabolic.
Kev tshawb nrhiav pom:
Ntau qhov kev tshawb fawb tau tshawb xyuas qhov cuam tshuam ntawm AHR antagonist 5 hauv vitro thiab hauv vivo. Ib txoj kev tshawb nrhiav pom tias AHR antagonist 5 txo qis qhov kev qhia ntawm pro-inflammatory cytokines thiab chemokines hauv cov hlwb kho nrog lipopolysaccharide (LPS), cov kab mob endotoxin uas ua rau lub cev tiv thaiv kab mob. Lwm txoj kev tshawb nrhiav pom tias AHR antagonist 5 inhibited kev loj hlob ntawm cov qog nqaij hlav cancer mis hauv vitro.
Hauv cov qauv tsiaj, AHR antagonist 5 tau pom tias txhim kho insulin rhiab heev thiab txo adiposity hauv cov nas rog rog. Nws kuj tau pom tias txo qhov mob thiab fibrosis hauv tus qauv nas ntawm daim siab raug mob.

Physicochemical Properties

Cov ntaub ntawv

1. Tian Y, Ke S, Denison MS, et al. Ib qho kev xaiv aryl hydrocarbon receptor modulator 3,3'-diindolylmethane inhibits gastric cancer cell loj hlob [J]. Molecular carcinogenesis, 2015, 54(8): 712-721.

2. Dong J, Sulik KK, Chen SY. Lub Aryl Hydrocarbon Receptor Pathway txhais lub sij hawm ncej rau Susceptibility los cuam tshuam ntawm leej niam haus luam yeeb rau Cerebral 5-HT2A Receptor Binding nyob rau hauv txiv neej Offspring[J]. Frontiers nyob rau hauv neuroscience, 2017, 11: 312.

3. Rizzo G, Nigro E, Taverniti L, et al. Cov teebmeem ntawm diindolylmethane supplementation ntawm qib qis hauv tsev menyuam cytological abnormalities: ob-dig muag, randomized, tswj kev sim [J]. American Journal of Obstetrics and Gynecology, 2014, 211(6): 567.

URK-V2458_COA

URK-V2458_SDS

URK-V2458_TDS

Cim npe nrov: AHR Antagonist 5 CAS No.: 2247953-39-3, Tuam Tshoj AHR Antagonist 5 CAS No.: 2247953-39-3