STING Activator Compound 53 CAS No.:2259624-71-8

Chemical Structure: STING activator Compound 53

CAS Nr.: 2259624-71-8

 

STING activator Compound 53(STING agonist C53)

Catalog No.Qauv: URK-V2345Tsuas yog siv rau Lab.

STING activator Compound 53 yog lub zog me me molecule activator ntawm tib neeg STING nrog kev ua haujlwm EC50 ntawm 183 nM hauv immortalized thiab thawj cov hlwb.

Kev ua lom lom

STING activator Compound 53 yog lub zog me me molecule activator ntawm tib neeg STING nrog kev ua haujlwm EC50 ntawm 183 nM hauv immortalized thiab thawj cov hlwb.
Compound 53 ncaj qha activates STING los ntawm thoob plaws cov protein ntau sib txawv nyob rau hauv tib neeg cov pej xeem thiab los ntawm ob qho tib si recombinant thiab thawj hlwb.
Compound 53 induces ib tug dav vaj huam sib luag ntawm cytokines thiab cov cim ntawm dendritic cell maturation raws li nws ua rau STING.
Compound 53 khi rau lub hnab tsho cryptic hauv STING transmembrane domain, nruab nrab ntawm ob lub subunits ntawm STING dimer. txhawb nqa lub oligomerization thiab ua kom tib neeg STING los ntawm lub tshuab orthogonal rau ntawm cGAMP.
Compound 53 ua rau sab nrauv hloov pauv ntawm transmembrane helices nyob rau hauv lub dimer, thiab induces inter-dimer kev sib cuam tshuam ntawm cov helices los kho qhov tsim ntawm high-order oligomer.

Physicochemical Properties

Cov ntaub ntawv

1. Lu D, et al. Xwm. 2022 Apr 6. doi: 10.1038/s41586-022-04559-7.

2. David C Pryde, et al. Eur J Med Chem. 2021 Peb 1, 209:112869.

URK-V2345_COA

URK-V2345_SDS

URK-V2345_TDS

 

Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!

Cim npe nrov: sting activator compound 53 cas no.:2259624-71-8