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BMS -1166 Hydrochloride CAS No.: 2113650-05-6

Chemical Structure: BMS{0}} hydrochloride
CAS Nr.: 2113650-05-6

Xa kev nug

Hauj lwm lawm

Chemical Structure: BMS{0}} hydrochloride

CAS Nr.: 2113650-05-6

BMS -1166 hydrochloride

Catalog No.Qauv: URK-V2479Tsuas yog siv rau Lab.

BMS-1166 hydrochloride (CAS No.: 2113650-05-6) yog ib qho tshiab me me molecule inhibitor, tshwj xeeb yog tsom rau PIM kinases, tsev neeg ntawm serine/threonine kinases.

Kev ua lom lom

BMS -1166 hydrochloride yog ib qho tshiab me me molecule inhibitor, tshwj xeeb tshaj yog tsom rau PIM kinases, tsev neeg ntawm serine/threonine kinases.
BMS{0}} muaj peev xwm los khi rau ATP-binding hnab tshos ntawm PIM kinases, tiv thaiv lawv kev ua kom muaj zog thiab qis qis qis.
BMS{0}} qhia txog kev xaiv siab rau PIM kinases, tsis muaj kev cuam tshuam loj rau lwm cov kinases lossis cellular txoj hauv kev.

Physicochemical Properties

M.Wt	677.57
Formula	C₃₆H₃₄Cl₂N₂O₇
CAS Nr.	2113650-05-6
Qhov tshwm sim	Khoom
Cia	Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos	Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis
Solubility
Tshuaj npe

Cov ntaub ntawv

1. Brown JR, et al. Kev nyab xeeb, pharmacokinetics, thiab pharmacodynamics ntawm ib tus neeg sawv cev BMS-1166 nyob rau hauv cov neeg mob uas muaj hematological malignancies siab heev: Thawj qhov tshwm sim los ntawm kev tshawb fawb theem 1/2a. 2019 American Society of Hematology.

2. Brault L, et al. PIM kinases yog cov hom phiaj kho mob hauv ntau yam myeloma. Ntshav. 2012; 119(3):{4}}.

3. Kadavakollu S, et al. PIM kinase inhibitors txhim khu kev ua tau zoo ntawm mammalian androgen receptor antagonists tawm tsam prostate cancer hlwb. Oncotarget. 2017; 8(19):{4}}.