Hauj lwm lawm
Chemical Structure: GCGR-IN-17
CAS Nr.: 1393124-08-7
GCGR-IN-17(PF-06291874;PF06291874;PF-6291874)
Catalog No.Qauv: URK-V735Tsuas yog siv rau Lab.
PF06291874 (GCGR-IN-17) yog lub zog muaj zog glucagon receptor antagonist nrog Ki ntawm 14 nM rau hGCGR.
Kev ua lom lom
PF06291874 (GCGR-IN-17) yog lub zog muaj zog glucagon receptor antagonist nrog Ki ntawm 14 nM rau hGCGR.
PF06291874 qhia tau hais tias zoo heev xaiv tiv thaiv lub vaj huam sib luag ntawm 69 receptors, ion channels, uptake sites thiab enzymes.
PF06291874 txo cov glucagon-elicited qabzib mus ncig ua si nyob rau hauv koob tshuaj-dep endent yam hauv nas.
PF06291874 qhia qis hauv vivo clearance thiab zoo heev qhov ncauj bioavailability nyob rau hauv cov nas thiab dev.
Physicochemical Properties
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M.Wt |
503.513 |
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Formula |
C26H28F3N3O4 |
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CAS Nr. |
1393124-08-7 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
DMSO: Ntau dua lossis sib npaug li 30 mg / mL |
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Tshuaj npe |
glucagon receptor antagonists-4, N-[4-[(1S)-1-[3,5-dimethyl-4-[4-(trifluoromethyl){ {9}}H-pyrazol-1-yl]phenoxy]butyl]benzoyl]- |
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Cov ntaub ntawv
1. Guzman-Perez A, et la. Bioorg Med Chem Lett. 2013 Tej zaum 15; 23(10):3051-8.
URK-V735_COAURK-V735_SDSURK-V735_TDS
Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: pf06291874 cas no.:1393124-08-7
Xa kev nug
Koj Tseem Yuav Zoo Li
