Hauj lwm lawm
Chemical Structure: CB1-IN-4
CAS Nr.: 1429239-98-4
CB1-IB-4(DBPR211, PEB 1184)
Catalog No.Qauv: URK-V650Tsuas yog siv rau Lab.
DBPR211 (BPRCB1184, CB1-IN-4) yog lub zog, xaiv, peripherally txwv cannabinoid-1 (CB1) receptor antagonist nrog Ki ntawm 0.3 nM, EC5{ {10}} ntawm 3.0 nM.
Kev ua lom lom
DBPR211 (BPRCB1184, CB1-IN-4) yog lub zog, xaiv, peripherally txwv cannabinoid-1 (CB1) receptor antagonist nrog Ki ntawm 0.3 nM, EC5{ {10}} ntawm 3.0 nM.
DBPR211 muaj qhov tsis tshua muaj tshwm sim los hla BBB raws li kev txwv tsis pub muaj CB1R antagonist, pom qhov ua tau zoo ntawm qhov hnyav hauv DIO nas.
DBPR211 kuj tseem qhia txog 163 qhov kev tshem tawm cov phiaj xwm thiab lub peev xwm los kho kev rog thiab cov kab mob metabolic cuam tshuam.
Physicochemical Properties
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M.Wt |
751.669 |
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Formula |
C33H31Cl2F3N6O3S2 |
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CAS Nr. |
1429239-98-4 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
10 mM hauv DMSO |
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Tshuaj npe |
1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-N-1-piperidinyl-4-[[(1-pyrrolidinylsulfonyl)amino] methyl]-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]- |
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Cov ntaub ntawv
1. Chang CP, et al. J Med Chem. 2013 Dec 27;56(24):9920-33.
2. Chun-Ping Chang, et al. Bioorg Med Chem. 2019 Jan 1; 27(1):216-223.
URK-V650_COAURK-V650_SDSURK-V650_TDS
Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: cb1-in-1 cas no.:1429239-98-4
Xa kev nug
Koj Tseem Yuav Zoo Li
