Hauj lwm lawm
Chemical Structure: TP-064
CAS Nr.: 2080306-20-1
TP -064(TP 064)
Catalog No.Qauv: URK-V604Tsuas yog siv rau Lab.
TP-064 yog lub zog, xaiv, thiab cell-active inhibitor ntawm PRMT4 nrog IC50 ntawm<10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) rau PRMT4 tshaj lwm PRMTs.
Kev ua lom lom
TP-064 yog lub zog, xaiv, thiab cell-active inhibitor ntawm PRMT4 nrog IC50 ntawm<10 nM and Kd of 7.1 nM.
TP-064 shows high selectivity (>100-fold) rau PRMT4 tshaj lwm PRMTs.
TP-064 txo cov dimethylation ntawm BAF155 (IC50=340± 30 nM) thiab MED12 (IC50=43± 10 nM) nyob rau hauv koob tshuaj raws li kev soj ntsuam ntawm tes.
TP-064 inhibits qhov kev loj hlob ntawm cov kab mob ntawm ntau cov kab mob myeloma (NCI-H929, RPMI8226, Cell IC50 ntawm 379 thiab 886 nM, raws li) nrog cov hlwb raug ntes hauv G1 theem ntawm lub voj voog ntawm tes, tab sis tsis muaj txiaj ntsig. ntawm mob myeloid leukemia, mob qog noj ntshav, lossis mob ntsws cancer ntawm tes.
Physicochemical Properties
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M.Wt |
458.606 |
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Formula |
C28H34N4O2 |
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CAS Nr. |
2080306-20-1 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
250 mM hauv DMSO (114.65 mg / mL) |
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Tshuaj npe |
N-methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4- yl)methyl){{ 8}}Phenoxybenzamide |
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Cov ntaub ntawv
1. Nakayama K, et al. Oncotarget. 2018 Plaub Hlis Ntuj 6; 9(26): 18480-18493.
URK-V604_COAURK-V604_SDSURK-V604_TDS
Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: tp064 cas no.: 2080306-20-1
Xa kev nug
Koj Tseem Yuav Zoo Li
