Hauj lwm lawm
Chemical Structure: PF-04418948
CAS Nr.: 1078166-57-0
PF-04418948
Catalog No.Qauv: URK-V649Tsuas yog siv rau Lab.
PF-04418948 (PF 04418948) yog ib qho tshiab muaj zog thiab xaiv prostaglandin EP2 receptor antagonist.
Kev ua lom lom
PF-04418948 (PF 04418948) yog ib qho tshiab muaj zog thiab xaiv prostaglandin EP2 receptor antagonist; inhibits prostaglandin E(2)(PGE(2))-induced nce nyob rau hauv cAMP nyob rau hauv hlwb nrog ib tug functional K(B) nqi ntawm 1.8 nM; attenuates cov butaprost-induced cutaneous ntshav txaus teb nyob rau hauv nas; hais lus nquag.
Lwm qhov taw qhia
Phase 1 Clinical
Physicochemical Properties
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M.Wt |
409.407 |
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Formula |
C23H20FNO5 |
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CAS Nr. |
1078166-57-0 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
10 mM hauv DMSO |
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Tshuaj npe |
3-Azetidinecarboxylic acid, 1-(4-fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]- |
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Cov ntaub ntawv
1. af Forselles KJ, et al. Br J Pharmacol. 2011 Dec; 164(7):1847-56.
2. Birrell MA, et al. Br J Pharmacol. 2013 Jan;168(1):129-38.
3. Kach J, et al. J Biol Chem. 2014 Mar 14; 289(11):7505-13.
URK-V649_COAURK-V649_SDSURK-V649_TDS
Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: pf-04418948 cas no.:1078166-57-0
Xa kev nug
Koj Tseem Yuav Zoo Li
