Hauj lwm lawm
Chemical Structure: A-485
CAS Nr.: 1889279-16-6
A-485(A485;A 485)
Catalog No.Qauv: URK-V689Tsuas yog siv rau Lab.
A-485 (A485) yog lub zog, xaiv thiab, ntawm tes thiab hauv vivo nquag p300 / CBP catalytic inhibitor nrog IC50 ntawm 9.8/2.6 nM.
Kev ua lom lom
A-485 (A485) yog lub zog, xaiv thiab, ntawm tes thiab hauv vivo nquag p300 / CBP catalytic inhibitor nrog IC50 ntawm 9.8/2.6 nM.
A-485 qhia kev xaiv rau p300/CBP tshaj lwm cov HATs thiab histone methyltransferases hauv hlwb.
A-485 koob tshuaj raws li txo H3K27Ac hauv prostate adenocarcinoma PC-3 hlwb nrog EC50 ntawm 73 nM.
A-485 xaiv inhibits kev loj hlob ntawm cov kab mob tshwj xeeb hauv cov qog nqaij hlav.
A-485 inhibits AR transcriptional program nyob rau hauv ob qho tib si androgen-sensitive thiab castration-resistant prostate cancer thiab inhibits qog loj hlob nyob rau hauv ib tug castration-resistant xenograft qauv.
Physicochemical Properties
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M.Wt |
536.484 |
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Formula |
C25H24F4N4O5 |
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CAS Nr. |
1889279-16-6 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
10 mM hauv DMSO |
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Tshuaj npe |
N-(4-fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,{ {9}}dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan{{ 20}}yl)acetamide |
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Cov ntaub ntawv
1. Lasko LM, et al. Xwm. 2017 Kaum Ib Hlis 5; 550(7674):128-132.
URK-V689_COAURK-V689_SDSURK-V689_TDS
Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: a-485 cas no.:1889279-16-6
Xa kev nug
Koj Tseem Yuav Zoo Li
