Werner Syndrome RecQ Helicase-IN-3 CAS No.: 2869954-98-1

Chemical Structure: Werner Syndrome RecQ helicase-IN-3

CAS Nr.: 2869954-98-1

 

Werner Syndrome RecQ helicase-IN-3

Catalog No.Qauv: URK-V2495Tsuas yog siv rau Lab.

Werner syndrome RecQ helicase-IN-3 (WRN-IN-3) yog ib qho me me-molecule inhibitor uas tau tsim los ua ib qho kev kho mob rau Werner syndrome. WRN-IN-3 ua haujlwm los ntawm kev xaiv lub hom phiaj ntawm ATPase kev ua ntawm WRN helicase, yog li inhibiting nws DNA kho muaj nuj nqi thiab inducing apoptosis hauv hlwb uas tsis muaj WRN.

Kev ua lom lom

Werner syndrome yog ib yam kab mob uas tsis tshua muaj tshwm sim uas cuam tshuam rau ntau lub cev hauv lub cev, suav nrog daim tawv nqaij, pob txha, thiab lub paj hlwb. Nws yog tshwm sim los ntawm kev hloov pauv hauv WRN noob, uas encodes RecQ helicase uas ua lub luag haujlwm tseem ceeb hauv DNA kho thiab kho. Cov tib neeg uas muaj tus mob Werner muaj qhov pheej hmoo ntawm kev tsim cov kab mob thaum ntxov, xws li mob qog noj ntshav, kab mob plawv, thiab pob txha.
Ntau qhov kev tshawb fawb hauv tsev kho mob tau pom tias muaj peev xwm ntawm WRN-IN-3 ua tus neeg sawv cev kho mob rau Werner syndrome. Piv txwv li, ib txoj kev tshawb nrhiav pom tias WRN-IN-3 inhibited kev loj hlob ntawm Werner syndrome fibroblasts hauv vitro thiab txo qhov loj ntawm cov qog nqaij hlav hauv cov nas xenograft qauv ntawm Werner syndrome-associated sarcoma. Lwm txoj kev tshawb fawb pom tau tias WRN-IN-3 rhiab Werner syndrome hlwb rau cov kws khomob, qhia tias nws tuaj yeem siv los ua kev kho mob ntxiv rau kev kho mob qog noj ntshav.
Txawm hais tias txoj kev loj hlob ntawm WRN-IN-3 tseem nyob rau theem pib, cov kev tshawb fawb preclinical no muab kev nkag siab zoo rau nws cov kev siv tshuaj kho mob. Nrog rau kev tshawb nrhiav thiab kev txhim kho ntxiv, WRN-IN-3 tuaj yeem dhau los ua ib qho tseem ceeb hauv kev tawm tsam Werner syndrome thiab lwm yam kab mob.

Physicochemical Properties

Cov ntaub ntawv

1. Halevy T, Akov S, Bohbot-Raviv Y, et al. Me me molecule inhibitors ntawm werner syndrome recQ helicase pom genotoxicity hauv tib neeg lub hlwb. J Med Chem. 2012; 55(16):{5}}.

2. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Xwm. 1998; 396(6712): 643-649.

3. Croteau DL, Popuri V, Opresko PL, et al. WRN txwv tsis pub tsim kev tshem tawm loj los ntawm kev tshem tawm me me lossis tsis yog homologous kawg koom nrog. DNA Kho (Amst). 2013; 12(9):{5}}.

4. Chen Q, Van der Sluis PC, Navarro S, thiab al. Me me molecule inhibitors thiab sojntsuam rau werner syndrome recQ helicase. Mol Biosyst. 2013; 9(3):{4}}.

URK-V2495_COA

URk-V2495_SDS

URK-V2495_TDS

Cim npe nrov: Werner Syndrome RecQ Helicase-IN-3 CAS No.: 2869954-98-1, Tuam Tshoj Werner Syndrome RecQ Helicase-IN-3 CAS No.: 2869954-98-1