Hauj lwm lawm
Chemical Structure: Adavosertib
CAS Nr.: 955365-80-7
Adavosertib(AZD-1775; MK-1775)
Catalog No.Qauv: URK-V1391Tsuas yog siv rau Lab.
Lub zog thiab xaiv me me-molecule inhibitor ntawm Wee1 kinase nrog IC50 ntawm 5.2 nM.
Kev ua lom lom
Lub zog thiab xaiv me me-molecule inhibitor ntawm Wee1 kinase nrog IC50 ntawm 5.2 nM; nthuav tawm ATP-kev sib tw thiab kev xaiv zoo rau lwm cov serine / threonine lossis tyrosine kinases; inhibits phosphorylation ntawm CDC2 ntawm Tyr15 hauv hlwb; potentiates qog loj hlob inhibition hauv vivo.
Mob ntsws cancer
Phase 2 Clinical
Physicochemical Properties
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M.Wt |
500.595 |
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Formula |
C27H32N8O2 |
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CAS Nr. |
955365-80-7 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
10 mM hauv DMSO |
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Tshuaj npe |
3H-Pyrazolo[3,4-d]pyrimidin-3-ib, 1,2-dihydro-1-[6-(1-hydroxy-1- }}methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-({17 }}propen-1-yl)- |
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Cov ntaub ntawv
1. Hirai H, et al. Mol Cancer Ther. Nov 2009; 8(11):2992-3000.
2. Hirai H, et al. Cancer Biol Ther. 2010 Plaub Hlis Ntuj 1; 9(7): 514-22.
3. Bridges KA, et al. Clin Cancer Res. 2011 Sep 1; 17(17):5638-48.
URK-V1199_COAURK-V1199_SDSURK-V1199_SDS
Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: mk-1775 cas no.:955365-80-7
Xa kev nug
Koj Tseem Yuav Zoo Li
