Werner Syndrome RecQ Helicase-IN-2 CAS No.: 2869954-51-6

Chemical Structure: Werner Syndrome RecQ helicase-IN-2

CAS Nr.: 2869954-51-6

 

Werner Syndrome RecQ helicase-IN-2

Catalog No.Qauv: URK-V2494Tsuas yog siv rau Lab.

Werner syndrome RecQ helicase-IN-2 (WRN-IN-2) yog lub hom phiaj zoo rau kev kho mob qog noj ntshav vim nws lub luag haujlwm hauv kev loj hlob ntawm cov qog nqaij hlav cancer.

Kev ua lom lom

WRN-IN-2 yog cov protein uas koom nrog DNA kev puas tsuaj kho thiab kho telomere. Dysfunctional WRN-IN-2 tuaj yeem ua rau mob qog noj ntshav thiab kev laus ntxov ntxov. Hauv kev mob qog noj ntshav, WRN-IN-2 txoj haujlwm yog los txhawb cov qog cell ciaj sia, tiv thaiv kev siv tshuaj khomob, thiab metastasis. Yog li ntawd, lub hom phiaj WRN-IN-2 qhia tau hais tias muaj peev xwm kho mob qog noj ntshav.
WRN-IN-2 inhibitors ua los ntawm kev thaiv cov kev ua ntawm cov protein thiab yuam cov qog nqaij hlav cancer rau hauv kev ntxhov siab, uas ua rau lawv cov DNA kho muaj nuj nqi thiab thaum kawg ua rau apoptosis.
Txoj kev loj hlob ntawm inhibitors
Ob peb WRN-IN-2 inhibitors tau raug txheeb xyuas, thiab lawv qhov ua tau hauv kev kho mob qog noj ntshav yog nyob rau hauv kev tshawb nrhiav. Cov tshuaj tiv thaiv zoo tshaj plaws yog nyob rau hauv chav kawm benzodiazepine thiab qhia tias muaj zog thiab kev xaiv rau WRN inhibition.
Kev txhawb nqa cov txiaj ntsig tau raug tshaj tawm hauv kev tshawb fawb ua ntej, thiab nws tau kwv yees tias WRN-IN-2 inhibitors tuaj yeem muaj txiaj ntsig zoo nrog rau lwm cov tshuaj tiv thaiv kab mob.
Kev siv ntawm WRN-IN-2 raws li lub hom phiaj kho mob qog noj ntshav yog ib lub tswv yim zoo, thiab kev txhim kho ntawm inhibitors tseem tsis tu ncua. Nws cia siab tias txoj hauv kev no yuav pab txhawb kev txhim kho kev kho mob qog noj ntshav yav tom ntej.

Physicochemical Properties

Cov ntaub ntawv

1. Kim HJ, Min SK, Ahn JY, Kwon T. WRN inhibitor muaj peev xwm ua tau raws li kev kho mob rau kev mob qog noj ntshav. Int J Mol Sci. Xyoo 2018; 19(2): 353.

2. Trujillo JP, Miret JJ, Pérez-Soler R, et al. Kev txheeb xyuas thiab ua tus cwj pwm ntawm cov tshiab inhibitors rau Werner helicase. Oncotarget. 2017; 8(56):{5}}.

3. Chen X, Ling JJ, Pena LA, et al. WRN inhibitor IBR612 inhibits kev loj hlob ntawm triple-negative mob qog noj ntshav mis. BMC Cancer. Xyoo 2019; 19(1): 416.

URK-V2494_COA

URk-V2494_SDS

URK-V2494_TDS

Cim npe nrov: Werner Syndrome RecQ Helicase-IN-2 CAS No.: 2869954-51-6, Tuam Tshoj Werner Syndrome RecQ Helicase-IN-2 CAS No.: 2869954-51-6