Hauj lwm lawm
Chemical Structure: G007-LK
CAS Nr.: 1380672-07-0
G007-LK(G007 LK; G007LK)
Catalog No.Qauv: URK-V1005Tsuas yog siv rau Lab.
G007-LK yog ib qho muaj zog, tshwj xeeb, metabolically ruaj khov TNKS1/2 inhibitor nrog IC50 ntawm 46 nM thiab 25 nM, feem.
Kev ua lom lom
G007-LK yog ib qho muaj zog, tshwj xeeb, metabolically ruaj khov TNKS1/2 inhibitor nrog IC50 ntawm 46 nM thiab 25 nM, feem; txo Wnt / -catenin signaling los ntawm kev tiv thaiv poly (ADP-ribosyl) ation-dependent AXIN degradation, yog li txhawb -catenin destabilization; ua haujlwm zoo thaiv ligand-tsav Wnt / -catenin signaling hauv kab lis kev cai ntawm tes thiab qhia kwv yees li 50 feem pua inhibition ntawm APC kev hloov pauv-tsav signaling nyob rau hauv feem ntau CRC kab ntawm tes, inhibits g ntawm nas plab hnyuv organoids cultured ex vivo nrog IC50 ntawm 80 nM; inhibits nyob rau hauv vivo qog loj hlob nyob rau hauv ib tug subset ntawm APC-mutant CRC xenograft qauv.
Physicochemical Properties
|
M.Wt |
529.958 |
|
|
Formula |
C25H16ClN7O3S |
|
|
CAS Nr. |
1380672-07-0 |
|
|
Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
|
Solubility |
DMSO: Ntau dua lossis sib npaug li 30 mg / mL |
|
|
Tshuaj npe |
Benzonitrile, 4-[5-[(1E)-2-[4-(2-chlorophenyl)-5-[5-(methylsulfonyl) -2-pyridinyl]-4H-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol -2-yl]- |
|
Cov ntaub ntawv
1. Voronkov A, et al. J Med Chem. 2013 Plaub Hlis Ntuj 11; 56(7):3012-23.
2. Lau T, et al. Cancer Res. 2013 Tsib Hlis 15; 73(10):3132-44.
URK-V1005_COAURK-V1005_SDSURK-V1005_TDS
Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: g007-lk cas no.:1380672-07-0
Xa kev nug
Koj Tseem Yuav Zoo Li
