Danicopan (Synonyms: ACH-4471) CAS No.: 1903768-17-1

Chemical Structure : Danicopan (Synonyms: ACH-4471)

CAS Nr.: 1903768-17-1

 

Danicopan(Synonyms: ACH-4471)

Catalog No.Qauv: URK-V2534Tsuas yog siv rau Lab.

Danicopan (ACH{{0}}) yog ib qho zoo thiab xaiv inhibitor ntawm cov khoom ntxiv D, nrog rau IC50 tus nqi ntawm 0.6 nM.

Kev ua lom lom

Danicopan(ACH{{0}}) yog ib qho zoo thiab xaiv inhibitor ntawm kev ua kom tiav D, nrog rau IC50 tus nqi ntawm 0.6 nM. Complement factor D yog ib qho serine protease uas cleaves yam B, uas ua rau lwm txoj hauv kev ntxiv ntxiv.
Danicopan(ACH-4471) tau pom tias yuav txwv tsis pub lwm txoj hauv kev ntxiv hauv vitro thiab hauv vivo, ua rau txo qis C3 deposition. Tsis tas li ntawd, danicopan tau pom tias muaj cov khoom siv tshuaj muaj txiaj ntsig zoo thiab ua kom pom cov tshuaj tiv thaiv kab mob ntawm qhov ua haujlwm D hauv cov tib neeg noj qab haus huv.
Tam sim no Danicopan tab tom raug tshuaj xyuas rau ntau yam kev qhia, suav nrog paroxysmal nocturnal hemoglobinuria, C3 glomerulopathy, thiab thaj chaw atrophy. Hauv theem 2 kev sim tshuaj rau cov neeg mob uas muaj paroxysmal nocturnal hemoglobinuria, danicopan tau pom tias txo qis hemolysis thiab nce qib hemoglobin piv rau cov placebo. Tsis tas li ntawd, theem 2 kev sim tshuaj rau C3 glomerulopathy tau pom tias txo qis hauv proteinuria thiab nce eGFR hauv cov neeg mob kho nrog danicopan.

Physicochemical Properties

Cov ntaub ntawv

1. Ricklin D, et al. Ua kom tiav-targeted therapeutics. Nat Biotechnol. 2017; 35(9):{5}}.

2. Risitano AM, et al. Danicopan: kev tshuaj xyuas ntawm cov ntaub ntawv kho mob thiab kho mob. Kws muaj txuj Rev Hematol. 2021; 14(1):{4}}.

3. Risitano AM, et al. Kev kawm theem 2 ntawm qhov ncauj ntxiv inhibitor danicopan rau paroxysmal nocturnal hemoglobinuria. Ntshav. 2019;133(9):{5}}.

4. Bomback AS, et al. Kev ua tau zoo thiab kev nyab xeeb ntawm qhov ncauj ntxiv inhibitor danicopan hauv C3 glomerulopathy. J Am Soc Nephrol. 2021; 32(4):{5}}.

URK-V2534_COA

URk-V2534_SDS

URK-V2534_TDS

Cim npe nrov: Danicopan (Synonyms: ACH-4471) CAS No.: 1903768-17-1, Tuam Tshoj Danicopan (Synonyms: ACH-4471) CAS No.: 1903768-17-1