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MK-0159 CAS No.: 2641484-61-7

Chemical Structure: MK-0159
CAS Nr.: 2641484-61-7

Xa kev nug

Hauj lwm lawm

Chemical Structure: MK-0159

CAS Nr.: 2641484-61-7

MK -0159

Catalog No.Qauv: URK-V2530Tsuas yog siv rau Lab.

MK-0159, tseem hu ua Balixafortide, yog ib qho tshiab thiab xaiv antagonist ntawm chemokine receptor CXCR4.

Kev ua lom lom

MK-0159, tseem hu ua Balixafortide, yog ib qho tshiab thiab xaiv antagonist ntawm chemokine receptor CXCR4.
Balixafortide kuj tseem muaj peev xwm siv tau raws li cov qia cell mobilizer. Los ntawm kev cuam tshuam CXCR4-SDF1 axis, Balixafortide tau pom tias txhawm rau txhawm rau hematopoietic qia hlwb mus rau hauv cov ntshav peripheral, ua rau lawv muaj ntau dua rau kev sau hauv cov neeg mob uas tau hloov cov qia cell.

Physicochemical Properties

M.Wt	400.49
Formula	C₂₀H₂₄N₄O₃S
CAS Nr.	2641484-61-7
Qhov tshwm sim	Khoom
Cia	Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos	Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis
Solubility
Tshuaj npe

Cov ntaub ntawv

1. Zhang Z, Ni C, Chen W. et al. Balixafortide (MK-0466) raws li kev kho mob monotherapy lossis kev sib xyaw ua ke nrog eribulin mesylate rau kev kho mob qog noj ntshav siab. OncoTargets Ther. Xyoo 2020; 13:393-401.

2. Ishikawa T, Nakashima S, Namba T. et al. Balixafortide, CXCR4 antagonist, inhibits qog hlav thiab txhim kho txoj sia nyob hauv tus qauv nas ntawm pancreatic ductal adenocarcinoma. Surg Hnub no. Peb Hlis 2020; 50(10):1224-1231.

3. Deng X, Ruan H, Zhang X. et al. Balixafortide, CXCR4 antagonist, txhim kho cov txiaj ntsig ntawm kev kho mob thiab txhim kho kev mob qog noj ntshav hauv cov neeg mob qog noj ntshav siab. Pem hauv ntej Oncol. Xyoo 2020; 10:43.

4. Fruehauf S, Seggewiss-Bernhardt R, Khandanpour C. et al. Balixafortide yog ib qho tshiab qia cell mobilizer nrog cov khoom siv dav dav. Ntshav. 2018; 132 (Suppl 1): 3034.