JAK 3i CAS No.: 1918238-72-8

Chemical Structure: JAK 3i

CAS Nr.: 1918238-72-8

 

JAJ 3 i

Catalog No.Qauv: URK-V2504Tsuas yog siv rau Lab.

JAK 3i yog ib tus neeg sib tw tshuaj muaj txiaj ntsig uas tau tsim los tiv thaiv kev ua haujlwm ntawm Janus Kinase 3 (JAK3), ib qho enzyme uas koom nrog txoj hauv kev taw qhia ntawm cytokines thiab kev loj hlob. JAK3 ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov kab mob inflammatory thiab autoimmune xws li mob caj dab rheumatoid, psoriasis, ntau yam sclerosis, thiab ulcerative colitis. Los ntawm kev xaiv hom phiaj JAK3, JAK 3i tuaj yeem muaj peev xwm muab kev kho mob tshiab rau cov kab mob no.

Kev ua lom lom

Lub hauv paus ntsiab lus ntawm JAK 3i qhov inhibitory kev txiav txim yog los ntawm kev khi rau ATP-binding site ntawm JAK3 thiab tiv thaiv cov phosphorylation thiab ua kom cov kev taw qhia hauv qab. Los ntawm inhibiting JAK3 kev ua ub no, JAK 3i tuaj yeem txo qis kev tsim cov cytokines thiab chemokines, thiab yog li txo qhov mob thiab cov ntaub so ntswg puas.
Nyob rau hauv xyoo tas los no, JAK inhibitors tau tshwm sim los ua ib qho kev cog lus ntawm cov tshuaj rau kev kho mob ntawm cov kab mob autoimmune. FDA tau pom zoo ob peb JAK inhibitors, suav nrog tofacitinib thiab baricitinib, rau kev kho mob rheumatoid mob caj dab. Txawm li cas los xij, cov tshuaj no muaj kev txwv ntawm kev ua tau zoo thiab kev nyab xeeb. JAK 3i, raws li kev xaiv JAK3 inhibitor, tej zaum yuav muaj kev nyab xeeb zoo dua thiab muaj kev cuam tshuam tsawg dua.
Ntau qhov kev tshawb fawb tau ua los tshawb xyuas qhov ua tau zoo thiab kev nyab xeeb ntawm JAK 3i hauv cov qauv tsiaj ntawm cov kab mob autoimmune. Cov kev tshawb fawb no tau pom cov txiaj ntsig tau zoo, ua kom pom tias JAK 3i tuaj yeem txo qhov mob thiab txo cov tsos mob ntawm tus kab mob.
Hauv kev xaus, JAK 3i yog tus neeg sib tw tshuaj pheej hmoo rau kev kho mob inflammatory thiab autoimmune kab mob, nrog rau cov txheej txheem tshwj xeeb ntawm kev ua thiab muaj peev xwm zoo dua li JAK inhibitors uas twb muaj lawm. Kev sim tshuaj ntxiv ntxiv yog xav tau los ntsuas nws cov txiaj ntsig thiab kev nyab xeeb hauv tib neeg cov neeg mob.

Physicochemical Properties

Cov ntaub ntawv

1. Kitzmüller C, Sexl V, Scherzer J, et al. Qhov cuam tshuam ntawm Janus kinase 3 inhibition ntawm kev tswj T hlwb: Ib txoj hauv kev kho tshiab hauv kab mob autoimmune? Pharmacol Ther. Xyoo 2020; 213: 107562.

2. Rubbert-Roth A, Guo Q, Biswas R, et al. Kev sim ntawm Upadacitinib thiab Abatacept nyob rau hauv Rheumatoid Arthritis (SELECT-EARLY): Ib Lub Chaw Ntau, Randomized, Ob Qhov Muag Pom Kev, Parallel-Group, Active Comparator-Controlled Phase 3 Trial. Lancet. 2021; 397(10277):{11}}.

3. Yiu ZZ, Krueger JG, Lebwohl MG. Dab tsi tshiab hauv Psoriasis Kev Tshawb Fawb thiab Kev Kho Mob? Dermatol Clin. 2021; 39(2):{4}}.

URK-V2504_COA

URk-V2504_SDS

URK-V2504_TDS

Cim npe nrov: JAK 3i CAS No.: 1918238-72-8, Tuam Tshoj JAK 3i CAS No.: 1918238-72-8