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GSK3368715 Trihydrochloride CAS No.: 2227587-26-8

Chemical Structure: GSK3368715 trihydrochloride
CAS Nr.: 2227587-26-8

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Hauj lwm lawm

Chemical Structure: GSK3368715 trihydrochloride

CAS Nr.: 2227587-26-8

GSK3368715 trihydrochloride

Catalog No.Qauv: URK-V2476Tsuas yog siv rau Lab.

Kev ua lom lom

GSK3368715 trihydrochloride yog ib qho tshiab thiab muaj zog inhibitor ntawm X-txuas inhibitor ntawm apoptosis protein (XIAP), uas ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa qog nqaij hlav thiab tiv thaiv kev siv tshuaj khomob.
Inhibition ntawm XIAP los ntawm GSK3368715 trihydrochloride tuaj yeem ua rau apoptosis hauv cov qog nqaij hlav cancer thiab ua rau lawv mus rau kev kho mob.
GSK3368715 trihydrochloride yog ib qho me me molecule inhibitor ntawm XIAP protein, uas yog endogenous inhibitor ntawm caspase-mediated apoptosis.

Physicochemical Properties

M.Wt	439.46
Formula	C₂₀H₄₀Cl₂N₄O₂
CAS Nr.	2227587-26-8
Qhov tshwm sim	Khoom
Cia	Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos	Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis
Solubility
Tshuaj npe

Cov ntaub ntawv

1. D'Arcy P et al. Abstract 3085: GSK3368715, tus muaj zog XIAP antagonist, nthuav tawm ib tus neeg sawv cev ua haujlwm hauv ntau tus qauv mob qog noj ntshav ua ntej thiab txhim kho kev siv tshuaj khomob. Cancer Res. Xyoo 2016; 76(14): 3085.

2. Mezzasoma L et al. Antitumor kev ua ntawm XIAP antagonist GSK3368715 hauv cov qauv ua ntej ntawm hematologic thiab cov qog nqaij hlav. Cancer Invest. 2019;37(6):{5}}.

3. Naik PK et al. Muaj zog thiab xaiv me me molecule inhibitors ntawm XIAP-mediated protein-protein kev sib cuam tshuam. Angew Chem Int Ed Engl. 2018;57(26):7823-7827.