Hauj lwm lawm
Chemical Structure: TAK-041
CAS Nr.: 1929519-13-0
TXAUS -041(NBI-1065846, TXK041)
Catalog No.Qauv: URK-V601Tsuas yog siv rau Lab.
TAK-041 (NBI-1065846) yog lub zog, xaiv, lub hlwb-penetrant GPR139 agonist nrog EC50 ntawm 22 nM (CHO-T-REx Ca2 plus assays), Ki ntawm 119 nM.
Kev ua lom lom
TAK-041 (NBI-1065846) yog lub zog, xaiv, lub hlwb-penetrant GPR139 agonist nrog EC50 ntawm 22 nM (CHO-T-REx Ca2 plus assays), Ki ntawm 119 nM.
TAK-041 txhim kho tus cwj pwm kev sib raug zoo hauv BALB/c nas, TAK-041 tau qhia GPR139-agonist-dependent modulation ntawm habenula cell kev ua thiab qhia tau zoo ib yam hauv vivo kev ua tau zoo los cawm kev sib raug zoo ntawm kev sib raug zoo hauv lub BALB/c nas strain.
TAK-041 (NBI-1065846) tam sim no tab tom txhim kho rau kev kho cov tsos mob tsis zoo hauv SCZ.
Physicochemical Properties
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M.Wt |
392.338 |
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Formula |
C18H15F3N4O3 |
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CAS Nr. |
1929519-13-0 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
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Tshuaj npe |
(S)-2-(4-Oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-({10}}({{11 }}(trifluoromethoxy)phenyl)ethyl)acetamide |
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Cov ntaub ntawv
1. Reichard HA, et al. J Med Chem. 2021 Aug 12;64(15):11527-11542.
2. Rabiner EA, et al. Neuropsychopharmacology. 21 Peb 2021.
URK-V601_COAURK-V601_SDSURK-V601_TDS
Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: tak041 cas no.: 1929519-13-0
Xa kev nug
Koj Tseem Yuav Zoo Li
