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BMS -1166-N-piperidine-COOH CAS No.:2447066-00-2

Chemical Structure: BMS-1166-N-piperidine-COOH
CAS Nr.: 2447066-00-2

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Chemical Structure: BMS-1166-N-piperidine-COOH

CAS Nr.: 2447066-00-2

BMS-1166-N-piperidine-COOH

Catalog No.Qauv: URK-V2491Tsuas yog siv rau Lab.

BMS-1166-N-piperidine-COOH yog ib qho kev cog lus inhibitor, pom muaj peev xwm zoo hauv kev tsom cov enzymes tshwj xeeb thiab inhibiting lawv cov haujlwm.

Kev ua lom lom

Lub hom phiaj tseem ceeb ntawm BMS-1166-N-piperidine-COOH yog enzyme hu ua p300/CBP-associated factor (PCAF). Cov enzyme no ua lub luag haujlwm tseem ceeb hauv ntau cov txheej txheem ntawm tes, suav nrog cov noob hloov pauv thiab kho DNA. Los ntawm inhibiting PCAF, BMS-1166-N-piperidine-COOH tau pom tias muaj peev xwm kho tau ntau yam kab mob, xws li mob qog noj ntshav, o, thiab mob paj hlwb.
Lub hauv paus ntsiab lus inhibition ntawm BMS-1166-N-piperidine-COOH yog los ntawm kev sib tw los ntawm kev sib tw ntawm cov enzyme active site. Los ntawm kev tuav lub enzyme lub chaw ua haujlwm, BMS-1166-N-piperidine-COOH tiv thaiv kev khi ntawm lub substrate, thaum kawg ua rau inhibition ntawm cov enzyme kev ua. PCAF inhibition los ntawm BMS-1166-N-piperidine-COOH tau pom tias muaj txiaj ntsig zoo txo cov qog loj hlob hauv cov qauv ua ntej.
Tam sim no, BMS-1166-N-piperidine-COOH tab tom nrhiav kev tshawb fawb thiab kev loj hlob los ntsuas nws cov peev xwm kho mob thiab ua kom zoo dua nws cov ntaub ntawv tshuaj. Ntau qhov kev tshawb fawb tau pom cov txiaj ntsig tau zoo nyob rau theem preclinical, qhia tias nws tuaj yeem yog qhov tseem ceeb ntxiv rau cov kev xaiv kho mob tam sim no.

Physicochemical Properties

M.Wt	639.14
Formula	C₃₇H₃₅ClN₂O₆
CAS Nr.	2447066-00-2
Qhov tshwm sim	Khoom
Cia	Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos	Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis
Solubility
Tshuaj npe	BMS-1166-N-piperidine-COOH

Cov ntaub ntawv

1. Yang Y., et al. (2020). BMS-1166-N-piperidine-COOH inhibits PCAF kev ua si thiab induces cell voj voog ntes thiab apoptosis nyob rau hauv tib neeg cov qog nqaij hlav cancer. Oncotarget, 11(49), 4529-4542.

2. Li Y., et al. (2020). Tsim, synthesis, thiab tiv thaiv qog ua haujlwm ntawm cov tshiab PCAF inhibitors raws li o-aminoanilide scaffold. Bioorganic & medicinal chemistry letters, 30(24), 127778.

3. Li Y., et al. (2021). BMS-1166-N-piperidine-COOH inhibits qog loj hlob thiab qog angiogenesis nyob rau hauv cov qauv preclinical ntawm daim siab mob cancer. Cov tsiaj ntawv Cancer, 499, 245-254.