Hauj lwm lawm
Chemical Structure: BLU9931
CAS Nr.: 1538604-68-0
PAB 9931 (BLU-9931)
Catalog No.Qauv: URK-V694Tsuas yog siv rau Lab.
BLU9931 (BLU-9931) yog ib qho muaj zog, xaiv, irreversible inhibitor ntawm FGFR4 nrog IC50 ntawm 3 nM, qhia ntau yam tsis muaj zog rau FGFR1 (IC50=591 nM), FGFR2 (IC50=493} nM ) thiab FGFR3 (IC{10}} nM).
Kev ua lom lom
BLU9931 (BLU-9931) yog ib qho muaj zog, xaiv, irreversible inhibitor ntawm FGFR4 nrog IC50 ntawm 3 nM.
BLU9931 qhia ntau yam tsis muaj zog rau FGFR1 (IC50=591 nM), FGFR2 (IC50=493 nM) thiab FGFR3 (IC50=150 nM).
BLU9931 muaj zog thiab xaiv inhibits FGFR4 signaling thiab cell proliferation nyob rau hauv HCC cell kab nrog ib tug activated FGFR4 signaling txoj kev (Huh-7 cell IC50=110 nM, JHH-7 IC50=20 nM) .
BLU9931 qhia tau hais tias zoo kawg nkaus antitumor kev ua hauv nas bearing HCC qog xenograft uas overexpresses FGF19.
Physicochemical Properties
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M.Wt |
509.384 |
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Formula |
C26H22Cl2N4O3 |
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CAS Nr. |
1538604-68-0 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
17 mg/ml hauv DMSO |
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Tshuaj npe |
2-Propenamide, N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl ]amino] -3-methylphenyl]- |
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Cov ntaub ntawv
1. Hagel M, et al. Cancer Discov. 2015 Apr;5(4):424-37.
2. Packer LM, et al. Cancer Discov. 2015 Apr;5(4):355-7.
3. Yamamoto M, et al. Cancer Sci. 2018 Mar 13. doi: 10.1111/cas.13569.
URK-V694_COAURK-V694_SDSURK-V694_TDSNco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: blu9931 cas no.:1538604-68-0
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