Hauj lwm lawm
Chemical Structure: ONO-7475
CAS Nr.: 1646839-59-9
ONO-7475 (NPO 7475)
Catalog No.Qauv: URK-V618Tsuas yog siv rau Lab.
ONO-7475 (ONO7475) yog ib qho muaj zog inhibitor ntawm TAM receptor tyrosine kinase tsev neeg (Axl IC50=0.7 nM), inhibits phosphorylation ntawm AXL thiab Mer, suppresses kev loj hlob ntawm AML nrog FLT3 kev hloov.
Kev ua lom lom
ONO-7475 (ONO7475) yog ib qho muaj zog inhibitor ntawm TAM receptor tyrosine kinase tsev neeg (Axl IC50=0.7 nM), inhibits phosphorylation ntawm AXL thiab Mer, suppresses kev loj hlob ntawm AML nrog FLT3 kev hloov.
ONO-7475 sensitizes AXL-expressing EGFR-mutant NSCLC hlwb rau EGFR-TKIs osimertinib thiab dacomitinib.
ONO-7475 suppresses qhov tshwm sim thiab kev saib xyuas ntawm EGFR-TKI-hloov hlwb, suppresses phosphorylation ntawm AKT, p70S6K, ERK, thiab EGFR. Kev sib xyaw ua ke ntawm ONO-7475 thiab osimertinib qeeb regrowth ntawm cell line-derived xenograft qog.
Osimertinib-hloov cov hlwb uas tau txais cov tshuaj tiv thaiv tsis zoo rau kev kho nrog osimertinib thiab ONO-7475.
Physicochemical Properties
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M.Wt |
562.582 |
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Formula |
C32H26N4O6 |
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CAS Nr. |
1646839-59-9 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
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Tshuaj npe |
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Cov ntaub ntawv
1. Okura N, et al. Clin Cancer Res. 2020 Tej zaum 1; 26(9): 2244-2256.
2. Ruvolo PP, thiab al. Haematologica. 2017 Dec; 102(12):2048-2057.
URK-V618_COAURK-V618_SDSURK-V618_TDSNco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: ono7475 cas no.:1646839-59-9
Xa kev nug
Koj Tseem Yuav Zoo Li
