4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine CAS No.: 1211520-73-8

Chemical Structure: 4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine

CAS Nr.: 1211520-73-8

 

4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine

Catalog No.Qauv: URK-V2471Tsuas yog siv rau Lab.

4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CTPP), ua haujlwm raws li kinase inhibitor, yog lub zog inhibitor ntawm cov protein. kinases CK1δ/ε.

Kev ua lom lom

4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CTPP), ua haujlwm raws li kinase inhibitor, yog lub zog inhibitor ntawm cov protein. kinases CK1δ / ε, uas koom nrog hauv kev tswj hwm ntau yam txheej txheem ntawm tes thiab tau cuam tshuam rau kev txhim kho mob qog noj ntshav, kab mob neurodegenerative, thiab cov kab mob metabolic.
Kev tshawb fawb tau pom tias CTPP muaj txiaj ntsig zoo hauv inhibiting CK1δ/ε cov haujlwm, thiab tau nthuav tawm cov txiaj ntsig tau zoo hauv kev tshawb fawb ua ntej raws li kev kho mob rau Huntington tus kab mob, mob qog noj ntshav mis, thiab Alzheimer's disease.

Physicochemical Properties

Cov ntaub ntawv

1. Mora A, Komander D, van Aalten DMF, Alessi DR. PDK1, tus tswv regulator ntawm AGC kinase teeb liab transduction. Semin Cell Dev Biol. 2004; 15(2):{5}}.

2. Tao J, Wu H, Lin Q, et al. Cov qauv thiab kev ua haujlwm ntawm cov protein ntau tshwj xeeb Kinase CK1δ Modulator. Cell Chem Bio. 2019;26(8):{5}}.e10.

3. Xiao X, Yu J, Wu D, et al. Kev txheeb xyuas thiab kev ua yam ntxwv ntawm ib qho tshwj xeeb inhibitor ntawm CK1ε. J Mol Cell Biol. 2016; 8(1):{5}}.

4. Silva JM, Rodrigues J, Sola P, et al. Lub pyrrolo[2,3-d]pyrimidine derivative CTPP inhibits qog nqaij hlav cancer ntawm lub mis los ntawm kev txhawb p53-mediated apoptosis. Eur J Med Chem. 2014; 87:675-682.

URK-V2471_COA

URK-V2471_SDS

URK-V2471_TDS

Cim npe nrov: 4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine CAS No.: 1211520-73-8, Suav teb 4-Chloro -5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine CAS No.: 1211520-73-8