Hauj lwm lawm
Chemical Structure: BLU-945
CAS Nr.: 2660250-10-0
BLU-945 (BLU 945)
Catalog No.Qauv: URK-V2327Tsuas yog siv rau Lab.
BLU-945 yog lub zog, mutant-xaiv inhibitor ntawm EGFR T790M / C797S thiab EGFR ntxiv / T790M kev hloov pauv (IC50<1 nM).
Kev ua lom lom
BLU-945 yog lub zog, mutant-xaiv inhibitor ntawm EGFR T790M / C797S thiab EGFR ntxiv / T790M kev hloov pauv (IC50<1 nM).
BLU-945 inhibits EGFRex19del/T790M/C797S, EGFRL858R/T790M/C797S, EGFRex19del/T790M, and EGFRL858R/T790M mutants with sub-nanomolar IC50 values in an enzyme assay, with >1000-fold selectivity dhau EGFR WT.
BLU-945 ua tiav txoj kev muaj zog EGFR txoj hauv kev inhibition hauv NCI-H1975 EGFRL858R/T790M, Ba/F3 EGFRL858R/T790M/C797S, thiab Ba/F3 EGFRex19del/T790M/C797S ntawm tes inhibition rau cov kab loj loj.
Kev tswj hwm qhov ncauj ntawm BLU-945 rau cov nas qog nqaij hlav tau pom muaj zog EGFR txoj hauv kev inhibition thiab tiv thaiv qog ua haujlwm ntawm cov koob tshuaj tiv thaiv zoo nyob rau hauv subcutaneous NCI-H1975 CDX qauv, thiab osimertinib-resistant CDX thiab PDX qauv.
Physicochemical Properties
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M.Wt |
557.701 |
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Formula |
C28H37FN6O3S |
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CAS Nr. |
2660250-10-0 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
10 mM hauv DMSO |
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Tshuaj npe |
N-(2-((3S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)-5-isopropyl{{9} }}((2R,3S)-2-methyl-3-((methylsulfonyl)methyl)azetidin{14}}yl)isoquinolin-3-amine |
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Cov ntaub ntawv
1. Sun Min Lim, et al. Cancer Res (2021) 81 (13_Supplement): 1467.
URK-V2327_COAURK-V2327_SDSURK-V2327_TDSNco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: blu945 cas no.:2660250-10-0
Xa kev nug
Koj Tseem Yuav Zoo Li
