Tsev - Cov khoom - Inhibitors & Agonists - Lwm tus - Paub meej

PF-07258669 CAS No.: 2755890-53-8

Chemical Structure: PF-07258669
CAS Nr.: 2755890-53-8

Xa kev nug

Hauj lwm lawm

Chemical Structure: PF-07258669

CAS Nr.: 2755890-53-8

PF-07258669

Catalog No.Qauv: URK-V2513Tsuas yog siv rau Lab.

PF-07258669 yog ib qho kev xaiv thiab muaj zog inhibitor ntawm cov protein kinase enzyme hu ua PI3Kδ.

Kev ua lom lom

PF-07258669 yog ib qho kev xaiv thiab muaj zog inhibitor ntawm cov protein kinase enzyme hu ua PI3Kδ.
PF-07258669 muaj zog inhibitory cuam tshuam ntawm PI3Kδ, nrog IC50 tus nqi tsawg dua 10 nM. Nws kuj tau pom tias muaj kev xaiv zoo rau lub hom phiaj no, nrog rau cov teebmeem me me ntawm lwm yam PI3K enzymes.
PF-07258669 tau pom tias muaj txiaj ntsig zoo hauv kev kho mob inflammatory thiab kab mob autoimmune.
Nws tau pom tias muaj txiaj ntsig zoo hauv kev txo qis kev ua haujlwm ntawm B hlwb thiab T hlwb, uas paub tias yuav pab txhawb rau cov xwm txheej no.
PF-07258669 tej zaum yuav muaj peev xwm kho tau cov kab mob xws li mob caj dab rheumatoid, lupus, thiab ntau yam sclerosis.

Physicochemical Properties

M.Wt	462.52
Formula	C₂₅H₂₇FN₆O₂
CAS Nr.	2755890-53-8
Qhov tshwm sim	Khoom
Cia	Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos	Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis
Solubility
Tshuaj npe

Cov ntaub ntawv

1. Yang Q, et al. Discovery of PF-07258669: Ib qho muaj zog PI3Kδ Inhibitor nrog Macrocyclic Architecture rau Kev Kho Mob Kab Mob thiab Kab Mob autoimmune. J Med Chem. 2021 Apr 8. doi: 10.1021/acs.jmedchem.0c01651.

2. Martin AL, et al. Ib qho tshiab, muaj zog, thiab xaiv phosphoinositide 3-kinase δ (PI3Kδ) inhibitor blocks leukocyte recruitment hauv o. J Biol Chem. 2021 Peb 30: 100595. doi: 10.1016/j.jbc.2021.100595.