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DLin-MC4-DMA CAS No.: 1226909-66-5

Chemical Structure: DLin-MC4-DMA
CAS Nr.: 1226909-66-5

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Hauj lwm lawm

Chemical Structure: DLin-MC4-DMA

CAS Nr.: 1226909-66-5

DLin-MC4-DMA

Catalog No.Qauv: URK-V2468Tsuas yog siv rau Lab.

DLin-MC4-DMA tsom rau cov molecules tshwj xeeb ntawm cov kab mob qog noj ntshav, tso cai rau kom muaj txiaj ntsig zoo thiab muaj txiaj ntsig zoo ntawm cov tshuaj kho mob.

Kev ua lom lom

DLin-MC4-DMA system yog ua raws li lub hauv paus ntsiab lus ntawm kev xa tshuaj tsom, uas suav nrog kev txuas lub hom phiaj rau tus neeg sawv cev kho mob. Lub hom phiaj molecule lees paub thiab khi tshwj xeeb rau cov molecules ntawm cov kab mob qog noj ntshav, tso cai rau tus neeg kho mob xa ncaj qha mus rau cov qog nqaij hlav cancer.
Ib qho txiaj ntsig tseem ceeb ntawm DLin-MC4-DMA system yog nws qhov tshwj xeeb thiab rhiab heev. Vim hais tias lub hom phiaj molecule tuaj yeem paub txog cov molecules tshwj xeeb ntawm cov kab mob qog noj ntshav, nws tuaj yeem xaiv xa cov tshuaj kho mob rau cov hlwb no, thaum tawm hauv cov hlwb kom tsis txhob kov. Qhov no txo cov kev pheej hmoo cuam tshuam nrog kev siv tshuaj khomob, uas feem ntau ua rau cov kev mob tshwm sim tsis zoo xws li plaub hau poob thiab xeev siab.
Cov kev tshawb fawb tsis ntev los no tau pom tias DLin-MC4-DMA muaj txiaj ntsig zoo hauv kev xa ntau yam tshuaj kho mob rau cov hlwb, suav nrog cov molecules me, peptides, thiab siRNA. Hauv ib txoj kev tshawb fawb, cov kws tshawb fawb tau siv DLin-MC4-DMA los xa cov tshuaj me me rau cov qog nqaij hlav qog nqaij hlav prostate, uas ua rau muaj qhov txo qis hauv qog loj.
DLin-MC4-DMA yog ib qho kev cog lus xa tshuaj uas muaj peev xwm los hloov kho mob qog noj ntshav. Nws qhov tshwj xeeb thiab rhiab heev ua rau nws yog ib qho kev xaiv zoo nkauj rau kev xa ntau yam tshuaj kho mob rau cov qog nqaij hlav cancer, thaum txo qis qhov kev pheej hmoo ntawm cov kev mob tshwm sim tsis zoo. Kev tshawb fawb ntxiv yog xav tau los txiav txim siab tag nrho lub peev xwm ntawm cov thev naus laus zis tshiab no.

Physicochemical Properties

M.Wt	655.627
Formula	C44H81NO2
CAS Nr.	1226909-66-5
Qhov tshwm sim	Khoom
Cia	Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos	Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis
Solubility
Tshuaj npe	(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 5-(dimethylamino) pentanoate

Cov ntaub ntawv

1. Akinc A, Maier MA, Manoharan M, Fitzgerald K, et al. Zaj dab neeg Onpattro thiab kev kho mob txhais lus ntawm nanomedicines uas muaj cov tshuaj nucleic acid. Nanotechnol. 2019 May; 14(5): 1084-1087.

2. Tadayoni-Rebekah Z, Tiu A, Gregoire M, et al. De novo design, synthesis, and evaluation of DLin-MC4-DMA-based lipids for mRNA delivery in vitro and in vivo. Biomacromolecules. 2021 Jan 11; 22(1):240-256.

3. Chou DH, Webber MJ, Tang BC, et al. Glucose-responsive insulin ua haujlwm los ntawm covalent hloov kho nrog aliphatic phenylboronic acid conjugates. Proc Natl Acad Sci US A. 2015 Lub Xya Hli 28; 112(30):9577-82.