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HSMG-1 Inhibitor 11j CAS No.:1402452-15-6

HSMG-1 Inhibitor 11j CAS No.:1402452-15-6

Chemical Structure: hSMG{0}} inhibitor 11j
CAS Nr.: 1402452-15-6

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Chemical Structure: hSMG{0}} inhibitor 11j

CAS Nr.: 1402452-15-6

product-279-207

 

 

 

 

hSMG{0}} inhibitor 11j

Catalog No.Qauv: URK-V2332Tsuas yog siv rau Lab.

hSMG{{0}} inhibitor 11j yog lub zog, xaiv hSMG-1 kinase inhibitor nrog IC5 0 ntawm 0.11 nM, 455-fold selectivity tshaj mTOR thiab tsis muaj kev cuam tshuam rau CDK1 /2.

 

Kev ua lom lom

hSMG{{0}} inhibitor 11j yog lub zog, xaiv hSMG-1 kinase inhibitor nrog IC5 0 ntawm 0.11 nM, 455-fold selectivity dhau mTOR thiab tsis ua haujlwm tawm tsam CDK1/2; tshem tawm UPF1 phosphorylation ntawm 1 uM thiab txo qis nws ntawm 0.3 uM, qhia me ntsis tshwm sim ntawm phospho p70s6 K thiab phospho AKT, lub hom phiaj ntawm mTOR thiab PI3K; kuj qhia tau hais tias zoo inhibition nyob rau hauv MDA468 cell proliferation assay nrog ib tug IC50 ntawm 75 nM, muab ib lub cuab tam compound los soj ntsuam hSMG-1 kho mob qog biology.

 

Physicochemical Prkev ua haujlwm

M.Wt

566.077

Formula

C27H28ClN7O3S

CAS Nr.

1402452-15-6

Cia

Hmoov hmoov

-20 degree 3 xyoos;

4 degree 2 xyoos

Hauv Solvent

-80 degree 6 Lub Hlis

-20 degree 1 Lub Hlis

Solubility

10 mM hauv DMSO

Tshuaj npe

2-chloro-N, N-diethyl-5-((4-(2-(4-(3-}methylureido)phenyl)pyridin)-4-} }}yl)pyrimidin-2-yl)amino)benzenesulfonamide

 

Cov ntaub ntawv

1. Gopalsamy A, thiab al. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41.

 

product-80-80URK-V2332_COA
product-80-80URK-V2332_SDS
product-80-80URK-V2332_TDS
 

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Cim npe nrov: hsmg-1 inhibitor 11j cas no.:1402452-15-6

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