Hauj lwm lawm
Chemical Structure: MYLS22
CAS Nr.: 306959-01-3
MAS 22(TSI 22)
Catalog No.Qauv: URK-V2320Tsuas yog siv rau Lab.
MYLS22 yog ib qho tshwj xeeb, tsis muaj tshuaj lom me me molecule inhibitor ntawm sab hauv mitochondrial membrane mitochondrial fusion protein optic atrophy 1 (OPA1), curtails qog loj hlob thiab metastasisin vitro thiab hauv vivo.
Kev ua lom lom
MYLS22 yog ib qho tshwj xeeb, tsis muaj tshuaj lom me me molecule inhibitor ntawm sab hauv mitochondrial membrane mitochondrial fusion protein optic atrophy 1 (OPA1), curtails qog loj hlob thiab metastasisin vitro thiab hauv vivo. MYLS22 downregulates angiogenic yam (FGFR, FGF, EGF, thiab PDGF) siv los ntawm cov qog escaping ntawm VEGF inhibitors. MYLS22 (peritumoral txhaj 10 mg / kg / tuag) txo cov qog loj hlob, tsis pom muaj cov nyhuv ntxiv hauv Opa1 ntxiv / ΔEC nas. Pharmacological OPA1 inhibition ntawm MYLS22 txo cov qog nqaij hlav hauv lub mis hauv vitro.
Physicochemical Prkev ua haujlwm
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M.Wt |
443.52 |
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Formula |
C24H21N5O2S |
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CAS Nr. |
306959-01-3 |
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Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
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Solubility |
10 mM hauv DMSO |
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Tshuaj npe |
N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl) -3-methyl-1-phenyl-1H-thieno[2,{15}}c]pyrazole-5-carboxamide |
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Cov ntaub ntawv
1. Herkenne S, et al. Cell Metab. 2020 Tej zaum 5; 31(5):987-1003.e8.
2. Corrado M, et al. Cell tuag txawv. 2021 Jul;28(7):2194-2206.
URK-V2271_COAURK-V2271_SDSURK-V2271_TDSNco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: myls22 cas no.:306959-01-3
Xa kev nug
Koj Tseem Yuav Zoo Li
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