Hauj lwm lawm
Chemical Structure: CFI02
CAS Nr.: 273735-28-7
CFI 02(CFI 02; CFI-02)
Catalog No.Qauv: URK-V2341Tsuas yog siv rau Lab.
CFI02 (CFI-02) yog ib qho tshwj xeeb inhibitor ntawm human cytomegalovirus (HCMV) glycoprotein B-mediated fusion nrog IC50 ntawm 40 nM tiv thaiv kev kuaj HCMV hom AD169.
Kev ua lom lom
CFI02 (CFI-02) is a specific inhibitor of human cytomegalovirus (HCMV) glycoprotein B-mediated fusion with IC50 of 40 nM against laboratory adapted HCMV strain AD169; reduces HCMV yield by >3 logs at 1 uM, and shows no inhibitory activity against closely related betaherpesviruses (including MCMV, simian CMV, and RCMV) (IC50>20 uM) as well as cytotoxic effect (CC50>50 UAS).
Physicochemical Properties
|
M.Wt |
491.43 |
|
|
Formula |
C18H11F6N5OS2 |
|
|
CAS Nr. |
273735-28-7 |
|
|
Cia |
Hmoov hmoov -20 degree 3 xyoos; 4 degree 2 xyoos |
Hauv Solvent -80 degree 6 Lub Hlis -20 degree 1 Lub Hlis |
|
Solubility |
10 mM hauv DMSO |
|
|
Tshuaj npe |
N-(4-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)phenyl)-1,2,3-thiadiazole{{8} } carboxamide |
|
Cov ntaub ntawv
1. Jones TR, et al. J Virol. 2004 Feb; 78(3):1289-300.
2. Bloom JD, et al. Bioorg Med Chem Lett. 2003 Sep 1; 13(17):2929-32.
URK-V2341_COAURK-V2341_SDSURK-V2341_TDS
Nco tseg: Tag nrho cov khoom ntawm Ureiko tsuas yog siv rau kev tshawb fawb tshawb fawb lossis kev tshaj tawm daim ntawv pov thawj tshuaj, thiab peb tsis muab cov khoom thiab cov kev pabcuam rau kev siv tus kheej!
Cim npe nrov: cfi02 cas no.:273735-28-7
Xa kev nug
Koj Tseem Yuav Zoo Li
