BMS-1166-N-piperidine-CO-N-piperazine yog ib qho muaj zog thiab xaiv inhibitor ntawm protein tyrosine phosphatase 1B (PTP1B)

BMS-1166-N-piperidine-CO-N-piperazine yog ib qho muaj zog thiab xaiv inhibitor ntawm protein tyrosine phosphatase 1B (PTP1B). Nws ua raws li allosteric inhibitor ntawm PTP1B, thiab tau pom tias txhawm rau txhim kho insulin rhiab heev thiab txhim kho cov piam thaj homeostasis hauv kev tshawb fawb preclinical.

Ntxiv rau nws qhov kev siv hluav taws xob uas muaj peev xwm kho tau rau hom 2 mob ntshav qab zib mellitus thiab lwm yam kab mob metabolic, BMS-1166-N-piperidine-CO-N-piperazine kuj tau tshawb xyuas rau nws cov khoom tiv thaiv kab mob. Nws tau raug pom tias inhibit qhov kev loj hlob thiab kev loj hlob ntawm tib neeg cov qog nqaij hlav qog noj ntshav, thiab ua kom cov qog nqaij hlav cancer rau cov teebmeem ntawm kev siv tshuaj khomob.

Zuag qhia tag nrho, BMS-1166-N-piperidine-CO-N-piperazine sawv cev rau txoj kev vam meej rau kev tsim kho tshiab rau cov kab mob metabolic thiab oncologic. Nws cov kev xaiv thiab kev muaj peev xwm ua rau nws yog ib qho cuab yeej tseem ceeb rau kev tshawb xyuas lub luag haujlwm ntawm PTP1B hauv cov kab mob no, thiab nws lub peev xwm los hloov kho cov tshuaj insulin rhiab heev thiab mob qog noj ntshav ua rau nws muaj peev xwm kho mob tshiab rau cov neeg mob.

Cov ntaub ntawv:

1. Zhang Z.Y. Protein tyrosine phosphatase: qauv thiab kev ua haujlwm, substrate tshwj xeeb, thiab inhibitor kev loj hlob. Annu Rev Pharmacol Toxicol. 2002; 42:209-34.

2. Zhang J, et al. BMS-1166-N-piperidine-CO-N-piperazine, muaj zog thiab xaiv inhibitor ntawm protein tyrosine phosphatase 1B, txhim kho cov cim qhia insulin hauv vitro thiab hauv vivo. Biochem Biophys Res Commun. 2010; 393(3):{10}}.

3. Han S, et al. BMS-1166-N-piperidine-CO-N-piperazine sensitizes qog cell mus rau kws khomob los ntawm kev tsom rau cov protein tyrosine phosphatase 1B. Cancer Lett. 2015; 359(1):{10}}.