Ninerafaxstat Trihydrochloride CAS No.: 2311824-72-1

Chemical Structure: Ninerafaxstat trihydrochloride

CAS Nr.: 2311824-72-1

 

Ninerafaxstat trihydrochloride

Catalog No.Qauv: URK-V2497Tsuas yog siv rau Lab.

Ninerafaxstat trihydrochloride yog ib qho kev cog lus me me-molecule inhibitor tsom rau IGF-1R kinase, uas yog overexpressed nyob rau hauv ntau cov qog nqaij hlav thiab txhawb kev loj hlob ntawm tes thiab txoj kev ciaj sia.

Kev ua lom lom

Ninerafaxstat trihydrochloride yog ib qho kev cog lus me me-molecule inhibitor tsom rau IGF-1R kinase, uas yog overexpressed nyob rau hauv ntau cov qog nqaij hlav thiab txhawb kev loj hlob ntawm tes thiab txoj kev ciaj sia. Qhov inhibitor no ua haujlwm los ntawm kev tiv thaiv kev ua kom IGF-1R thiab cov kev taw qhia qis qis, ua rau cov cell tuag hauv cov qog nqaij hlav cancer.
Txoj kev loj hlob ntawm Ninerafaxstat trihydrochloride tau pom muaj peev xwm zoo hauv kev tshawb fawb txog kev kho mob thiab kev kho mob. Hauv kev tshawb fawb preclinical, Ninerafaxstat trihydrochloride tau qhia txog kev ua haujlwm ntawm cov qog nqaij hlav hauv ntau yam mob qog noj ntshav hauv vitro thiab hauv vivo. Hauv kev sim tshuaj ntsuam xyuas, Ninerafaxstat trihydrochloride tau qhia txog kev nyab xeeb thiab kev tiv thaiv kev tiv thaiv zoo thaum tseem qhia cov yam ntxwv zoo ntawm pharmacodynamic thiab pharmacokinetic.
Tam sim no, Ninerafaxstat trihydrochloride tab tom kawm nyob rau hauv ntau qhov kev sim Phase I/II hauv cov neeg mob uas muaj cov qog nqaij hlav. Tsis tas li ntawd, tus inhibitor no tseem raug tshawb xyuas ua ke nrog lwm cov tshuaj tiv thaiv thiab tshuaj khomob txhawm rau txhim kho cov lus teb thiab ua kom muaj sia nyob tag nrho hauv cov neeg mob qog noj ntshav.

Physicochemical Properties

Cov ntaub ntawv

1. Kojima K, Konopleva M, McQueen T, et al. MDM2 antagonists induce p53-dependent apoptosis hauv AML: cuam tshuam rau kev kho mob leukemia. Ntshav. 2005; 106(9): 3150–3159.

2. Shangary S, Wang S. Me-molecule inhibitors ntawm MDM2-p53 protein-protein kev sib cuam tshuam los ua kom rov ua haujlwm p53: txoj hauv kev tshiab rau kev kho mob qog noj ntshav. Ann Rev Pharmacol Toxicol. 2009; 49:223–241.

3. Wasylishen AR, Loignon M, Awrey DE, et al. Kev tshawb nrhiav thiab kev ua kom zoo ntawm cov tshiab macrocyclic MDM2 inhibitors uas qhib p53 hauv vitro thiab hauv vivo. J Med Chem. 2019; 62(16): 7515–7536. doi: 10.1021/acs.jmedchem.9b00322.

URK-V2497_COA

URk-V2497_SDS

URK-V2497_TDS

Cim npe nrov: Ninerafaxstat Trihydrochloride CAS No.: 2311824-72-1, Tuam Tshoj Ninerafaxstat Trihydrochloride CAS No.: 2311824-72-1