PS-423 (CAS No.:1221964-37-9) muaj peev xwm zoo los ua tus neeg sawv cev kho mob
Tso lus
PS-423(CAS No.:1221964-37-9) yog ib qho tshuaj lom neeg tawm tshiab, uas tau pom tias muaj peev xwm ua tau zoo raws li tus neeg sawv cev kho mob vim nws lub peev xwm los cuam tshuam qee cov proteins uas cuam tshuam rau txoj kab mob.
Lub hom phiaj tseem ceeb ntawm PS-423 yog protein tyrosine phosphatase 1B (PTP1B), ib qho tseem ceeb enzyme hauv kev taw qhia cov tshuaj insulin thiab cov piam thaj metabolism. Inhibition ntawm PTP1B tau pom tias yuav ua rau muaj kev nkag siab zoo ntawm cov tshuaj insulin, ua rau PS-423 yog tus neeg sib tw tshuaj zoo rau kev kho mob ntshav qab zib hom 2.
Ntxiv rau nws cov teebmeem ntawm PTP1B, PS-423 kuj tau qhia txog kev ua haujlwm inhibitory tiv thaiv ntau lwm cov protein tyrosine phosphatase, nrog rau cov protein tyrosine kinases. Qhov kev ua haujlwm dav dav no ua rau nws muaj peev xwm sib tw rau kev kho mob ntawm ntau yam kab mob, suav nrog mob qog noj ntshav, kab mob neurodegenerative, thiab mob inflammatory.
Tam sim no, ob peb qhov kev tshawb fawb soj ntsuam tau ua los ntawm kev siv PS-423 hauv tib neeg. Txawm li cas los xij, kev tshawb fawb preclinical tau pom nws txoj kev nyab xeeb thiab ua tau zoo hauv cov qauv tsiaj, muab kev txhawb zog rau nws lub peev xwm los ua tus neeg sawv cev kho.
Txoj kev loj hlob ntawm PS-423 raws li tus neeg sib tw tshuaj yog tseem nyob rau theem pib, thiab xav tau kev tshawb fawb ntxiv thiab kev sim tshuaj ua ntej nws tuaj yeem siv dav hauv kev kho mob. Txawm li cas los xij, nws cov khoom tshwj xeeb inhibitory thiab cov txiaj ntsig kho tau zoo ua rau nws qhov chaw zoo siab ntawm kev tshawb fawb rau kev tsim kho tshiab rau ntau yam kab mob.
Cov ntaub ntawv:
1. Celik H, et al. PTP1B inhibitors rau kev kho mob ntshav qab zib: kev tshuaj xyuas patent. Expert Opin Ther Pat. 2016; 26(12):{5}}.
2. Sun JP, et al. PS-423, muaj zog thiab tshwj xeeb inhibitor ntawm protein-tyrosine phosphatase 1B. Biochem Biophys Res Commun. 2007; 357(2):{7}}.
3. Li H., et al. Inhibition ntawm protein tyrosine phosphatase los ntawm ursolic acid thiab oleanolic acid: cuam tshuam rau kev tiv thaiv thiab kho mob qog noj ntshav. Cancer Lett. 2010; 298(2):{4}}.
